Hematopoietic stem cell (HSC) aging, which is accompanied by reduced self-renewal ability,
impaired homing, myeloid-biased differentiation, and other defects in hematopoietic …

Individual cells are basic units of life. Despite extensive efforts to characterize the cellular
heterogeneity of different organisms, cross-species comparisons of landscape dynamics …

Epigenetic memory is an essential process of life that governs the inheritance of predestined
functional characteristics of normal cells and the newly acquired properties of cells affected …

Regulatory dependencies in molecular networks are the basis of dynamic behaviors
affecting the phenotypical landscape. With the advance of high throughput technologies, the …

Hematopoietic stem cell (HSC) transplantation is the only curative therapy for many
diseases. HSCs from umbilical cord blood (UCB) source have many advantages over from …

Hematopoietic stem cells (HSCs) provide all types of blood cells during the entire life of the
organism. HSCs are mainly quiescent and can eventually enter the cell cycle to differentiate …

Understanding the mechanism of how cholangiocytes (liver ductal cells) are activated upon
liver injury and specified to hepatocytes would permit liver regenerative medicine. Here we …

Hematopoietic stem cells (HSCs), which are multipotent and have the ability to self‐renew,
are frequently used in the treatment of hematological diseases and cancer. Small molecules …

Generation of hematopoietic stem/progenitor cells (HSPCs) via cell expansion or cell
reprogramming has been widely achieved by overexpression of transcription factors. Herein …

Introduction The human bone marrow microenvironment is composed of biological,
chemical and physical factors that act in a synergistic way to modulate hematopoietic stem …