The biological activity and structural diversity of natural products are unsurpassed by any
available synthetic screening libraries. As such, these privileged scaffolds serve as …

The increasing understanding of the role of nitric oxide (NO) in cancer biology has
generated significant progress in the use of NO donor-based therapy to fight cancer. These …

In spite of the development of a large number of novel anticancer drugs over the years,
Cancer remains as a prominent cause of death, worldwide. Numerous drugs that are …

Cancer is one of the diseases with high morbidity and mortality on a global scale.
Chemotherapy remains the primary treatment option for most cancer patients, including …

Berberine is multifunctional natural product with potential to treat diverse pathological
conditions. Its broad-spectrum anticancer effect through direct effect on cancer cell growth …

Cancer is a leading cause of mortality responsible for an estimated 10 million deaths
worldwide in 2020, and its incidence has been rapidly growing over the last decades …

Oridonin belongs to ent-kaurane tetracyclic diterpenoid and was first isolated from Isodon
species. It exhibits inhibitory activities against a variety of tumor cells, and pharmacological …

Triple-negative breast cancer (TNBC) is one of the most highly invasive and metastatic
breast cancers without safe and effective therapeutic drugs. The natural product oridonin is …

As a continuation of our research on developing potent and potentially safe anti-proliferative
agents, two series of novel Jiyuan Oridonin A-1, 2, 3-triazole-azole hybrids were designed …

A novel class of NO-donating protoberberine derivatives were synthesized and initially
evaluated for their anti-hepatocellular carcinoma activities. Most of the compounds exhibited …