Ca2+ release‐activated Ca2+ (CRAC) channels mediate a specific form of Ca2+ influx
called store‐operated Ca2+ entry (SOCE) that contributes to the function of many cell types …

The recruitment of neutrophils to sites of inflammation, their battle against invading
microorganisms through phagocytosis and the release of antimicrobial agents is a highly …

Kawasaki disease (KD) is a medium vessel vasculitis that affects young children. Despite
extensive research over the last 50 years, the etiology of KD remains an enigma. Seasonal …

Calcium signals are initiated in immune cells by the process of store-operated calcium entry
(SOCE), where receptor activation triggers transient calcium release from the endoplasmic …

The complement activation fragment C5a is a potent proinflammatory mediator that is
increasingly recognized as an immune modulator. C5a acts through two C5a receptors …

Phagocytic cells, such as neutrophils, macrophages, and dendritic cells, migrate to sites of
infection or damage and are integral to innate immunity through two main mechanisms. The …

Calcium is a major intracellular signaling messenger in innate immune cells. Similar to other
immune cell subsets, the majority of calcium entry into innate immune cells is induced by cell …

Kawasaki disease (KD; MIM# 61175) is a systemic vasculitis syndrome with unknown
etiology which predominantly affects infants and children. Recent findings of susceptibility …

The complement system significantly contributes to the development of inflammatory and
neuropathic pain, but the underlying mechanisms are poorly understood. Recently, we …

Acute pancreatitis is initiated within pancreatic exocrine cells and sustained by dysregulated
systemic inflammatory responses mediated by neutrophils. Store-operated Ca2+ entry …