Pathogenesis of human cytomegalovirus in the immunocompromised host

P Griffiths, M Reeves - Nature Reviews Microbiology, 2021 - nature.com
Human cytomegalovirus (HCMV) is a herpesvirus that infects~ 60% of adults in developed
countries and more than 90% in developing countries. Usually, it is controlled by a vigorous …

Balancing natural killer cell activation through paired receptors

L Martinet, MJ Smyth - Nature Reviews Immunology, 2015 - nature.com
Natural killer (NK) cells are innate lymphocytes that are crucial for the control of infections
and malignancies. NK cells express a variety of inhibitory and activating receptors that …

Generation of hypoimmunogenic T cells from genetically engineered allogeneic human induced pluripotent stem cells

B Wang, S Iriguchi, M Waseda, N Ueda… - Nature biomedical …, 2021 - nature.com
Avoiding the immune rejection of transplanted T cells is central to the success of allogeneic
cancer immunotherapies. One solution to protecting T-cell grafts from immune rejection …

Quantitative temporal viromics: an approach to investigate host-pathogen interaction

MP Weekes, P Tomasec, EL Huttlin, CA Fielding… - Cell, 2014 - cell.com
A systematic quantitative analysis of temporal changes in host and viral proteins throughout
the course of a productive infection could provide dynamic insights into virus-host …

Immunobiology of human cytomegalovirus: from bench to bedside

T Crough, R Khanna - Clinical microbiology reviews, 2009 - Am Soc Microbiol
Following primary infection, human cytomegalovirus (HCMV) establishes lifelong latency
and periodically reactivates without causing symptoms in healthy individuals. In the absence …

Activation, coactivation, and costimulation of resting human natural killer cells

YT Bryceson, ME March, HG Ljunggren… - Immunological …, 2006 - Wiley Online Library
Natural killer (NK) cells possess potent perforin‐and interferon‐γ‐dependent effector
functions that are tightly regulated. Inhibitory receptors for major histocompatibility complex …

Topics in herpesvirus genomics and evolution

DJ McGeoch, FJ Rixon, AJ Davison - Virus research, 2006 - Elsevier
Herpesviruses comprise an abundant, widely distributed group of large DNA viruses of
humans and other vertebrates, and overall are among the most extensively studied large …

CD 155, an onco‐immunologic molecule in human tumors

J Gao, Q Zheng, N Xin, W Wang, C Zhao - Cancer science, 2017 - Wiley Online Library
CD 155 is the fifth member in the nectin‐like molecule family, and functions as the receptor
of poliovirus; therefore, CD 155 is also referred to as necl‐5, or PVR. As an immunoglobulin …

Human cytomegalovirus latency: approaching the Gordian knot

F Goodrum - Annual review of virology, 2016 - annualreviews.org
Herpesviruses have evolved exquisite virus-host interactions that co-opt or evade a number
of host pathways to enable the viruses to persist. Persistence of human cytomegalovirus …

Expansion of CD94/NKG2C+ NK cells in response to human cytomegalovirus-infected fibroblasts

M Gumá, M Budt, A Sáez, T Brckalo, H Hengel… - Blood, 2006 - ashpublications.org
CD94/NKG2C+ natural killer (NK) cells are increased in healthy individuals infected with
human cytomegalovirus (HCMV), suggesting that HCMV infection may shape the NK cell …