Simple Summary The small ubiquitin-like modifier (SUMO) pathway regulates the hallmark
properties of cancer cells. Moreover, alterations in activity and in levels of SUMO machinery …

Abstract Karyopherin α2 (KPNA2, also known as importinα-1), a member of the nuclear
transporter family, is involved in the nucleocytoplasmic transport pathway of a variety of …

Treatments targeting oncogenic fusion proteins are notable examples of successful drug
development. Abnormal splicing of genes resulting in fusion proteins is a critical driver of …

Dengue virus and other flaviviruses such as the yellow fever, West Nile, and Japanese
encephalitis viruses are emerging vector‐borne human pathogens that affect annually more …

Cancer is one of the most studied areas of human biology over the past century. Despite
having attracted much attention, hype, and investments, the search to find a cure for cancer …

The glucocorticoid receptor (GR) is a member of the nuclear receptor superfamily of
transcription factors, which exerts anti-proliferative and anti-apoptotic activities. The GR is …

Lymphovascular invasion (LVI), the presence of malignant cells within lymphovascular
channels, is a crucial step in the invasion-metastasis cascade. LVI, when identified …

Background: It is recognised that modulations of the nuclear import of macromolecules have
a role in changing cellular phenotypes and carcinogenesis. We and others have noticed that …

SUMOylation, one of the most important posttranslational modifications of proteins, plays an
essential role in various biological processes; however, enzymes that control SUMOylation …

The initiation and progression of human prostate cancer are highly associated with aberrant
dysregulations of tumor suppressors and proto-oncogenes. Despite that deletions and …