The small ubiquitin‐like modifier, SUMO, can be covalently linked to specific proteins and
many substrates carrying this modification have been identified. However, for some proteins …

Sumoylation has important roles during DNA damage repair and responses. Recent broad-
scope and substrate-based studies have shed light on the regulation and significance of …

The promyelocytic leukemia (PML) protein organizes PML nuclear bodies (NBs), which are
stress-responsive domains where many partner proteins accumulate. Here, we clarify the …

DNA glycosylases safeguard the genome by locating and excising a diverse array of
aberrant nucleobases created from oxidation, alkylation, and deamination of DNA. Since the …

Significance: Reactive oxygen species (ROS) are generated by exogenous and
environmental genotoxins, but also arise from mitochondria as byproducts of respiration in …

Attachment of SUMO to proteins regulates protein-protein interactions through noncovalent
binding of the SUMO moiety to specialized SUMO interaction motifs (SIMs). A core of …

Ubiquitin (Ub) and ubiquitin-like (Ubl) modifiers such as SUMO (also known as Smt3 in
Saccharomyces cerevisiae) mediate signal transduction through post-translational …

The base excision repair system is vital to the repair of endogenous and exogenous DNA
damage. This pathway is initiated by one of several DNA glycosylases that recognizes and …

Cytosine methylation at CpG dinucleotides is a central component of epigenetic regulation
in vertebrates, and the base excision repair (BER) pathway is important for maintaining both …

The response to a DNA double-stranded break in mammalian cells is a process of sensing
and signalling the lesion. It results in halting the cell cycle and local transcription and in the …