Challenges in Peptide Solubilization–Amyloids Case Study
O Polańska, N Szulc, R Stottko, M Olek… - The Chemical …, 2024 - Wiley Online Library
Peptide science has been a rapidly growing research field because of the enormous
potential application of these biocompatible and bioactive molecules. However, many …
potential application of these biocompatible and bioactive molecules. However, many …
Exploring cross-α amyloids: from functional roles to design innovations
Amyloids are filamentous protein aggregates that have traditionally been associated with
neurodegenerative diseases, although they are also known to play pivotal functional roles …
neurodegenerative diseases, although they are also known to play pivotal functional roles …
Amyloid transformations of phenol soluble modulin α1 in Staphylococcus aureus and their modulation deploying a prenylated chalcone
N Admane, R Kothandan, S Biswas - Scientific Reports, 2024 - nature.com
Phenol soluble modulins (PSMs) are small amphipathic peptides involved in a series of
biological functions governing staphylococcal pathogenesis, primarily by facilitating the …
biological functions governing staphylococcal pathogenesis, primarily by facilitating the …
[HTML][HTML] Antimicrobial sensitisers: Gatekeepers to avoid the development of multidrug-resistant bacteria
H Wang, Y Yang, S Wang, S Badawy, I Ares… - Journal of Controlled …, 2024 - Elsevier
The resistance of multidrug-resistant bacteria to existing antibiotics forces the continued
development of new antibiotics and antibacterial agents, but the high costs and long …
development of new antibiotics and antibacterial agents, but the high costs and long …
Efficiently solving the curse of feature-space dimensionality for improved peptide classification
Machine learning is becoming an important tool for predicting peptide function that holds
promise for accelerating their discovery. In this paper, we explore feature selection …
promise for accelerating their discovery. In this paper, we explore feature selection …
β-lactam antibiotics induce metabolic perturbations linked to ROS generation leads to bacterial impairment
D Ye, J Sun, R Jiang, J Chang, Y Liu, X Wu… - Frontiers in …, 2024 - frontiersin.org
Understanding the impact of antibiotics on bacterial metabolism is crucial for elucidating
their mechanisms of action and developing more effective therapeutic strategies. β-lactam …
their mechanisms of action and developing more effective therapeutic strategies. β-lactam …
[HTML][HTML] Capturing the micro-communities: Insights into biogenesis and architecture of bacterial biofilms
Biofilm is an assemblage of microorganisms embedded within the extracellular matrix that
provides mechanical stability, nutrient absorption, antimicrobial resistance, cell-cell …
provides mechanical stability, nutrient absorption, antimicrobial resistance, cell-cell …
Pathogenesis-Associated Bacterial Amyloids: The Network of Interactions
H Fayoud, MV Belousov, KS Antonets… - Biochemistry (Moscow …, 2024 - Springer
Amyloids are protein fibrils with a characteristic cross-β structure that is responsible for the
unusual resistance of amyloids to various physical and chemical factors, as well as …
unusual resistance of amyloids to various physical and chemical factors, as well as …
[PDF][PDF] Mining and engineering activity in catalytic amyloids
S Peña-Díaz, P Ferreira, MJ Ramos… - Methods in Enzymology, 2024 - inano.au.dk
This chapter describes how to test different amyloid preparations for catalytic properties. We
describe how to express, purify, prepare and test two types of pathological amyloid (tau and …
describe how to express, purify, prepare and test two types of pathological amyloid (tau and …