The extracellular matrix (ECM) is synthesized and secreted by embryonic cells beginning at
the earliest stages of development. Our understanding of ECM composition, structure and …

The lens capsule is a modified basement membrane that completely surrounds the ocular
lens. It is known that this extracellular matrix is important for both the structure and …

Laminin, one of the most widely expressed extracellular matrix proteins, exerts many
important functions in multiple organs/systems and at various developmental stages …

Visual impairment and blindness is widespread across the human population, and the
development of therapies for ocular pathologies is of high priority. The zebrafish represents …

Ocular anterior segment dysgenesis (ASD) is a complex and poorly understood group of
conditions. A large proportion of individuals with ASD develop glaucoma, a leading cause of …

The Neuromutagenesis Facility at the Jackson Laboratory generated a mouse model of
retinal vasculopathy, nmf223, which is characterized clinically by vitreal fibroplasia and …

Purpose.: Alterations in FOXC1 dosage lead to a spectrum of highly penetrant, ocular
anterior segment dysgenesis phenotypes. The most serious outcome is the development of …

Integrins are the major cell surface receptors for proteins in the extracellular matrix. These
receptors form major cell signaling centers that are bidirectional, communicating messages …

purpose. In this study recessive zebrafish mutations in the genes encoding laminin β1
(lamb1) and laminin γ1 (lamc1) were used to determine the functions of these laminin …

Eye and inner ear diseases are the most common sensory impairments that greatly impact
quality of life. Zebrafish have been intensively employed to understand the fundamental …