The loss of skeletal muscle mass under a wide range of acute and chronic maladies is
associated with poor prognosis, reduced quality of life, and increased mortality. Decades of …

Muscle atrophy is caused by an imbalance in contractile protein synthesis and degradation
which can be triggered by various conditions including Type 2 Diabetes Mellitus (T2DM) …

Cancer cachexia is a systemic hypoanabolic and catabolic syndrome that diminishes the
quality of life of cancer patients, decreases the efficiency of therapeutic strategies and …

Autophagy is a critical process in the regulation of muscle mass, function and integrity. The
molecular mechanisms regulating autophagy are complex and still partly understood. Here …

Cachexia is a wasting syndrome characterized by pronounced skeletal muscle loss. In
cancer, cachexia is associated with increased morbidity and mortality and decreased …

Skeletal muscle provides a fundamental basis for human function, enabling locomotion and
respiration. Muscle loss occurs as a consequence of several chronic diseases (cachexia) …

Cancer cachexia is a complex multi‐organ catabolic syndrome that reduces mobility,
increases fatigue, decreases the efficiency of therapeutic strategies, diminishes the quality of …

Skeletal muscle is a highly adaptive tissue, capable of altering muscle fiber size, functional
capacity and metabolism in response to physiological stimuli. However, pathological …

Cancer cachexia is the progressive loss of skeletal muscle mass and adipose tissue,
negative nitrogen balance, anorexia, fatigue, inflammation, and activation of lipolysis and …

Cancer cachexia is a devastating metabolic syndrome characterized by systemic
inflammation and massive muscle and adipose tissue wasting. Although it is responsible for …