Supported molybdenum on graphene oxide/Fe3O4: An efficient, magnetically separable catalyst for one-pot construction of spiro-oxindole dihydropyridines in deep …

M Zhang, YH Liu, ZR Shang, HC Hu… - Catalysis Communications, 2017 - Elsevier
Magnetically separable graphene oxide supported molybdenum (Fe 3 O 4/GO-Mo)
nanoparticles were prepared and characterized by X-ray diffraction (XRD), scanning …

Calcium channel blockers' contribution to overcoming Current drug discovery challenges in Alzheimer's disease

PJ Bernard, D Bellili, L Ismaili - Expert Opinion on Drug Discovery, 2024 - Taylor & Francis
Introduction Alzheimer's disease (AD) is a progressive, irreversible, and multifactorial brain
disorder that gradually and insidiously destroys individual's memory, thinking, and other …

An Overview of Recent Advances in Hantzsch's Multicomponent Synthesis of 1, 4-Dihydropyridines: A Class of Prominent Calcium Channel Blockers

KK Saini, R Rani, Muskan, N Khanna… - Current Organic …, 2023 - benthamdirect.com
Among all the heterocyclic scaffolds, 1, 4-dihydropyridine (1, 4-DHPs) is an important class
of nitrogen-containing heterocyclic compounds possessing prominent therapeutic effects …

Multicomponent reactions as a privileged tool for multitarget-directed ligand strategies in Alzheimer's disease therapy

S Grosjean, I Pachón-Angona, M Dawra… - Future Medicinal …, 2022 - Taylor & Francis
Among neurodegenerative pathologies affecting the older population, Alzheimer's disease
is the most common type of dementia and leads to neurocognitive and behavioral disorders …

Sulfonated reduced graphene oxide (rGO-SO3H): A green, sustainable and efficient heterogeneous catalyst for synthesis of pyrazole containing 1, 4 dihydropyridine …

N Sharma, S Swami, VP Verma, R Nair… - Journal of Molecular …, 2025 - Elsevier
A simple mild, efficient, expeditious and straightforward synthetic methodology has been
established toward furnishing of therapeutically important structurally diverse multi …

DNA-binding activities of compounds acting as enzyme inhibitors, ion channel blockers and receptor binders

R Muhamadejevs, L Živković, M Dzintare… - Chemico-Biological …, 2021 - Elsevier
The DNA-binding activities of compounds used as remedies can display DNA-protection, but
also damaging effects in biological systems. The current review compiles literature data on …

Synthesis, docking simulation, biological evaluations and 3D-QSAR study of 1, 4-dihydropyridines as calcium channel blockers

TF El-Moselhy, PA Sidhom, EA Esmat… - Chemical and …, 2017 - jstage.jst.go.jp
Resurgence to target L-type voltage-dependent calcium channels has been applied by the
synthesis of two series of nifedipine analogues where the ortho-or a meta-nitrophenyl ring is …

[HTML][HTML] Selective Synthesis of the Aminobutadiene Intermediate and Mechanistic Analysis of 1, 4-Dihydropyridine Formation Reaction in Water

S Isomura, M Watanabe, A Suzuki, Y Okuno… - Chemical and …, 2022 - jstage.jst.go.jp
We previously isolated an aminobutadiene derivative as a by-product in the synthesis of a 1,
4-dihydropyridine (1, 4-DHP) derivative by the reaction of methyl propiolate with excess …