The genomes of influenza viruses consist of multiple segments of single-stranded negative-
sense RNA. Each of these segments is bound by the heterotrimeric viral RNA-dependent …

Coronavirus (CoV) genomes consist of positive-sense single-stranded RNA and are among
the largest viral RNAs known to date (∼ 30 kb). As a result, CoVs deploy sophisticated …

Principles of Virology, the leading virology textbook in use, is an extremely valuable and
highly informative presentation of virology at the interface of modern cell biology and …

Paramyxoviruses represent a family of RNA viruses causing significant human diseases.
These include measles virus, the most infectious virus ever reported, in addition to …

Segmented negative-strand RNA virus (sNSV) polymerases transcribe and replicate the
viral RNA (vRNA) within a ribonucleoprotein particle (RNP). We present cryo-EM and X-ray …

Negative-strand RNA viruses represent a significant class of important pathogens that cause
substantial morbidity and mortality in human and animal hosts worldwide. A defining feature …

The paramyxovirus family has a genome consisting of a single strand of negative sense
RNA. This genome acts as a template for two distinct processes: transcription to generate …

Negative-sense RNA viruses, such as influenza, encode large, multidomain RNA-
dependent RNA polymerases that can both transcribe and replicate the viral RNA genome …

Paramyxoviruses are enveloped, nonsegmented, negative-strand RNA viruses that cause a
wide spectrum of human and animal diseases. The viral genome, packaged by the …

Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract disease
in young children and a substantial contributor to respiratory tract disease throughout life …