In his seminal work, 1 Rolf Huisgen defined 1, 3-dipolar cycloadditions as “1, 3-Dipole, abc,
must be defined, such that atom a posseses an electron sextet, that is, an incomplete …

Multicomponent reactions (MCRs) receive increasing attention because they address both
diversity and complexity in organic synthesis. Thus, in principle diverse sets of relatively …

Optically pure nitrogenous compounds, and especially nitrogen-containing heterocycles,
have drawn intense research attention because of their frequent isolation as natural …

The stereocontrolled construction of chiral carbo-and heterocycles is a topic of paramount
importance in modern organic synthesis, driven by the predominance of chiral mono-and …

This review covers the use of 2-azaallyl anions, 2-azaallyl cations, and 2-azaallyl radicals in
organic synthesis up through June 2018. Particular attention is paid to both foundational …

Cycloaddition reactions are among the most important tools for the construction of cyclic
compounds in organic synthesis, since these reactions are vital to access natural products …

We have developed several multifunctional thiourea catalysts bearing a tertiary amine or an
1, 2-amino alcohol in expectation of their synchronous activation of a nucleophile and an …

The privileged spiro [pyrrolidin-3, 3′-oxindole] derivatives exhibit important biological
activities. An enantioselective organocatalytic approach to the rapid synthesis of spiro …

The catalytic asymmetric 1, 3-dipolar cycloaddition of azomethine ylides constitutes one of
the most powerful and atom economical methods for the enantioselective construction of …

Reactions in which several components are combined in sequence, and without isolation of
intermediates, are greatly sought because of the inherent molecular diversity, efficiency, and …