Causal mapping of human brain function

SH Siddiqi, KP Kording, J Parvizi, MD Fox - Nature reviews …, 2022 - nature.com
Mapping human brain function is a long-standing goal of neuroscience that promises to
inform the development of new treatments for brain disorders. Early maps of human brain …

Comorbid depression in medical diseases

SM Gold, O Köhler-Forsberg, R Moss-Morris… - Nature Reviews …, 2020 - nature.com
Depression is one of the most common comorbidities of many chronic medical diseases
including cancer and cardiovascular, metabolic, inflammatory and neurological disorders …

Stanford neuromodulation therapy (SNT): a double-blind randomized controlled trial

EJ Cole, AL Phillips, BS Bentzley… - American Journal of …, 2022 - Am Psychiatric Assoc
Objective: Depression is the leading cause of disability worldwide, and half of patients with
depression have treatment-resistant depression. Intermittent theta-burst stimulation (iTBS) is …

Stanford accelerated intelligent neuromodulation therapy for treatment-resistant depression

EJ Cole, KH Stimpson, BS Bentzley… - American Journal of …, 2020 - Am Psychiatric Assoc
Objective: New antidepressant treatments are needed that are effective, rapid acting, safe,
and tolerable. Intermittent theta-burst stimulation (iTBS) is a noninvasive brain stimulation …

Brain stimulation and brain lesions converge on common causal circuits in neuropsychiatric disease

SH Siddiqi, FL Schaper, A Horn, J Hsu… - Nature human …, 2021 - nature.com
Damage to specific brain circuits can cause specific neuropsychiatric symptoms.
Therapeutic stimulation to these same circuits may modulate these symptoms. To determine …

The role of the dorsolateral prefrontal cortex for speech and language processing

I Hertrich, S Dietrich, C Blum… - Frontiers in human …, 2021 - frontiersin.org
This review article summarizes various functions of the dorsolateral prefrontal cortex
(DLPFC) that are related to language processing. To this end, its connectivity with the left …

Distinct symptom-specific treatment targets for circuit-based neuromodulation

SH Siddiqi, SF Taylor, D Cooke… - American Journal of …, 2020 - Am Psychiatric Assoc
Objective: Treatment of different depression symptoms may require different brain
stimulation targets with different underlying brain circuits. The authors sought to identify such …

A transdiagnostic network for psychiatric illness derived from atrophy and lesions

JJ Taylor, C Lin, D Talmasov, MA Ferguson… - Nature human …, 2023 - nature.com
Psychiatric disorders share neurobiology and frequently co-occur. This neurobiological and
clinical overlap highlights opportunities for transdiagnostic treatments. In this study, we used …

Dissecting diagnostic heterogeneity in depression by integrating neuroimaging and genetics

AM Buch, C Liston - Neuropsychopharmacology, 2021 - nature.com
Depression is a heterogeneous and etiologically complex psychiatric syndrome, not a
unitary disease entity, encompassing a broad spectrum of psychopathology arising from …

Using brain imaging to improve spatial targeting of transcranial magnetic stimulation for depression

RFH Cash, A Weigand, A Zalesky, SH Siddiqi… - Biological …, 2021 - Elsevier
Transcranial magnetic stimulation (TMS) is an effective treatment for depression but is
limited in that the optimal therapeutic target remains unknown. Early TMS trials lacked a …