Hypoxia triggers several mechanisms to adapt cells to a low oxygen environment.
Mitochondria are major consumers of oxygen and a potential source of reactive oxygen …

During the last 40 years, there has been a world-wide increase in both the prevalence of
obesity and an increase in the number of persons over the age of 60 due to a decline in …

Ageing, like obesity, is often associated with alterations in metabolic and inflammatory
processes resulting in morbidity from diseases characterised by poor metabolic control …

The important role of mitochondria in the regulation of white adipose tissue (WAT)
remodeling and energy balance is increasingly appreciated. The remarkable heterogeneity …

The average length of telomere repeats (TL) declines with age and is considered to be a
marker of biological ageing. Here, we measured TL in six blood cell types from 1046 …

Age associated chronic inflammation is a major contributor to diseases with advancing age.
Adipose tissue function is at the nexus of processes contributing to age-related metabolic …

Adipose tissue has a variety of diverse functions that maintain energy homeostasis. In
conditions of excess energy availability, adipose tissue increases its lipid storage and …

Mitochondrial dysfunction, a hallmark of aging, has been associated with the onset of aging
phenotypes and age-related diseases. Here, we report that impaired mitochondrial function …

The hypothalamus plays a major role in the regulation of food intake and energy
expenditure. In the last decade, it was demonstrated that consumption of high-fat diets …

Adipose tissue is the most important energy storage organ in the body, maintaining its
normal energy metabolism function and playing a vital role in keeping the energy balance of …