The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

Oxidative stress has become widely viewed as an underlying condition in a number of
diseases, such as ischemia–reperfusion disorders, central nervous system disorders …

Aims To evaluate the impact of galangin treatment on cerebral ischemia-reperfusion (I/R)
injury in gerbils and to identify potential mechanisms of the protective effect of galangin on …

Growing evidence suggests that type 2 diabetes mellitus (DM) is associated with age-
dependent Alzheimer's disease (AD), the latter of which has even been considered as type 3 …

Abstract Peroxynitrite (ONOO−)-mediated mitophagy activation represents a vital pathogenic
mechanism in ischemic stroke. Our previous study suggests that ONOO− mediates Drp1 …

Reactive nitrogen species (RNS) play important roles in mediating cerebral ischemia-
reperfusion injury. RNS activate multiple signaling pathways and participate in different …

The nuclear factor erythroid-derived 2-related factor 2 (NFE2L2/Nrf2) is a pivotal facilitator of
cytoprotective responses against the oxidative/electrophilic insults. Upon activation, Nrf2 …

Tissue plasminogen activator (t-PA) is the only FDA-approved drug for acute ischemic stroke
treatment, but its clinical use is limited due to the narrow therapeutic time window and …

Alzheimer's disease (AD) is one of the most common neurodegenerative diseases and is
associated with disrupted cognition and behavior. Neuroinflammatory pathogenesis is the …

Peroxisome proliferator-activated receptor gamma (PPARgamma) has already been
considered as an attractive therapeutic target for the treatment of metabolic disorders …