Bayesian statistics allow scientists to easily incorporate prior knowledge into their data
analysis. Nonetheless, the sheer amount of computational power that is required for …

Background Unraveling the mechanisms that regulate gene expression is a major challenge
in biology. An important task in this challenge is to identify regulatory elements, especially …

We describe a new ab initio algorithm, GeneMark-ES version 2, that identifies protein-coding
genes in fungal genomes. The algorithm does not require a predetermined training set to …

Computational methods for discovery of sequence elements that are enriched in a target set
compared with a background set are fundamental in molecular biology research. One …

With the recent exponential increase in protein phosphorylation sites identified by mass
spectrometry, a unique opportunity has arisen to understand the motifs surrounding such …

In a conventional view of the prokaryotic genome organization, promoters precede operons
and ribosome binding sites (RBSs) with Shine-Dalgarno consensus precede genes …

One of the greatest challenges that modern molecular biology is facing is the understanding
of the complex mechanisms regulating gene expression. A fundamental step in this process …

The mechanisms of blood vessel maturation into distinct parts of the blood vasculature such
as arteries, veins, and capillaries have been the subject of intense investigation over recent …

As a step toward a comprehensive description of lignin biosynthesis in Populus trichocarpa,
we identified from the genome sequence 95 phenylpropanoid gene models in 10 protein …

Stem cell function during organogenesis is a key issue in developmental biology. The
transcription factor SHORT-ROOT (SHR) is a critical component in a developmental pathway …