The NACHT, leucine-rich repeat (LRR), and pyrin domain (PYD)-containing protein 3 (NLRP3) inflammasome is an intracellular sensing protein complex that plays a major role in …
Heart failure exhibits remarkable pathophysiologic heterogeneity. A large body of evidence suggests that regardless of the underlying etiology, heart failure is associated with induction …
The intracellular sensing protein termed NLRP3 (for NACHT, LRR, and PYD domains- containing protein 3) forms a macromolecular structure called the NLRP3 inflammasome …
Advances in our understanding of how the gut microbiota contributes to human health and diseases have expanded our insight into how microbial composition and function affect the …
Cardiac injury remains a major cause of morbidity and mortality worldwide. Despite significant advances, a full understanding of why the heart fails to fully recover function after …
S Toldo, A Abbate - Nature Reviews Cardiology, 2018 - nature.com
The heart is extremely sensitive to ischaemic injury. During an acute myocardial infarction (AMI) event, the injury is initially caused by reduced blood supply to the tissues, which is …
S Toldo, A Abbate - Nature Reviews Cardiology, 2024 - nature.com
An intense, stereotyped inflammatory response occurs in response to ischaemic and non- ischaemic injury to the myocardium. The NACHT, LRR and PYD domains-containing protein …
N Ruparelia, JT Chai, EA Fisher… - Nature reviews …, 2017 - nature.com
Inflammatory processes are firmly established as central to the development and complications of cardiovascular diseases. Elevated levels of inflammatory markers have …
Heart failure is considered an epidemic disease in the modern world affecting approximately 1% to 2% of adult population. It presents a multifactorial, systemic disease, in which—after …