Challenges in Monte Carlo simulations as clinical and research tool in particle therapy: a review

S Muraro, G Battistoni, AC Kraan - Frontiers in Physics, 2020 - frontiersin.org
The use and interest in Monte Carlo (MC) techniques in the field of medical physics have
been rapidly increasing in the past years. This is the case especially in particle therapy …

[图书][B] Monte Carlo techniques in radiation therapy

J Seco, F Verhaegen - 2013 - api.taylorfrancis.com
Monte Carlo simulation techniques made a slow entry in the field of radiotherapy in the late
1970s. Since then they have gained enormous popularity, judging by the number of papers …

Biological rationale and clinical evidence of carbon ion radiation therapy for adenoid cystic carcinoma: a narrative review

P Loap, B Vischioni, M Bonora, R Ingargiola… - Frontiers in …, 2021 - frontiersin.org
Adenoid cystic carcinoma (ACC) is a rare, basaloid, epithelial tumor, arising mostly from
salivary glands. Radiation therapy can be employed as a single modality for unresectable …

Intensity modulated proton therapy plan generation in under ten seconds

M Matter, L Nenoff, G Meier, DC Weber, AJ Lomax… - Acta …, 2019 - Taylor & Francis
Background: Treatment planning for intensity modulated proton therapy (IMPT) can be
significantly improved by reducing the time for plan calculation, facilitating efficient sampling …

Hypoxia‐informed RBE‐weighted beam orientation optimization for intensity modulated proton therapy

P Ramesh, D Ruan, SJ Liu, Y Seo… - Medical …, 2024 - Wiley Online Library
Background Variable relative biological effectiveness (RBE) models in treatment planning
have been proposed to optimize the therapeutic ratio of proton therapy. It has been reported …

Robust radiobiological optimization of ion beam therapy utilizing Monte Carlo and microdosimetric kinetic model

J Ma, HSWC Tseung, L Courneyea… - Physics in Medicine …, 2020 - iopscience.iop.org
Abstract To develop a Monte Carlo (MC)-based and robust ion beam therapy optimization
system that separates the optimization algorithm from the relative biological effectiveness …

A mechanistic relative biological effectiveness model-based biological dose optimization for charged particle radiobiology studies

F Guan, C Geng, DJ Carlson, DH Ma… - Physics in Medicine …, 2018 - iopscience.iop.org
In charged particle therapy, the objective is to exploit both the physical and radiobiological
advantages of charged particles to improve the therapeutic index. Use of the beam scanning …

Technological Developments and Future Perspectives in Particle Therapy: A Topical Review

AC Kraan, A Del Guerra - IEEE Transactions on Radiation and …, 2024 - ieeexplore.ieee.org
In the last decades, important technological progress has been made to enhance the quality
and efficiency of particle therapy treatments. Continuous improvements in dose delivery …

Simultaneous optimization of RBE-weighted dose and nanometric ionization distributions in treatment planning with carbon ions

LN Burigo, J Ramos-Méndez, M Bangert… - Physics in Medicine …, 2019 - iopscience.iop.org
Inverse treatment planning in intensity modulated particle therapy (IMPT) with scanned
carbon–ion beams is currently based on the optimization of RBE-weighted dose to satisfy …

Fixed beamline optimization for intensity modulated carbon-ion therapy

P Ramesh, H Liu, W Gu, K Sheng - IEEE transactions on …, 2021 - ieeexplore.ieee.org
A major obstacle for the adoption of heavy ion therapy is the cost and technical difficulties to
construct and maintain a rotational gantry. Many heavy ion treatment facilities instead …