As an evolutionarily conserved signalling network, the Hippo pathway plays a crucial role in
the regulation of numerous biological processes. Thus, substantial efforts have been made …

The Hippo pathway is an evolutionarily conserved signalling pathway with key roles in
organ development, epithelial homeostasis, tissue regeneration, wound healing and …

YAP and TAZ are highly related transcriptional regulators pervasively activated in human
malignancies. Recent work indicates that, remarkably, YAP/TAZ are essential for cancer …

The transcriptional regulators YAP and TAZ are the focus of intense interest given their
remarkable biological properties in development, tissue homeostasis and cancer. YAP and …

The transcriptional co‐activators YAP (or YAP1) and TAZ (or WWTR1) are frequently
activated during the growth and progression of many solid tumors, including lung, colorectal …

The Hippo pathway controls organ size in diverse species, whereas pathway deregulation
can induce tumours in model organisms and occurs in a broad range of human carcinomas …

The Hippo pathway has been implicated in suppressing tissue overgrowth and tumor
formation by restricting the oncogenic activity of YAP. However, transcriptional regulators …

Most cancer cells are exposed to altered extracellular environments, such as an increase in
extracellular matrix (ECM) stiffness and soluble signals consisting of growth factors and …

The transcriptional coactivator Yes-associated protein (YAP) is a major regulator of organ
size and proliferation in vertebrates. As such, YAP can act as an oncogene in several tissue …

The Hippo signaling pathway, also known as the Salvador− Warts− Hippo pathway, is a
regulator of organ size. The pathway takes its name from the Drosophila protein kinase …