Candida Infections and Therapeutic Strategies: Mechanisms of Action for Traditional and Alternative Agents

GC de Oliveira Santos, CC Vasconcelos… - Frontiers in …, 2018 - frontiersin.org
The Candida genus comprises opportunistic fungi that can become pathogenic when the
immune system of the host fails. Candida albicans is the most important and prevalent …

Diagnosis and management of cryptococcal meningitis in HIV-infected adults

TC McHale, DR Boulware, J Kasibante… - Clinical microbiology …, 2023 - Am Soc Microbiol
Cryptococcal meningitis is a leading cause of morbidity and mortality globally, especially in
people with advanced HIV disease. Cryptococcal meningitis is responsible for nearly 20% of …

Phenoconversion due to drug–drug interactions in CYP2C19 genotyped healthy volunteers

K Abouir, N Exquis, Y Gloor, Y Daali… - Clinical Pharmacology …, 2024 - Wiley Online Library
To compensate for drug response variability, drug metabolism phenotypes are determined
based on the results of genetic testing, and if necessary, drug dosages are adjusted. In …

Chronic pulmonary aspergillosis—where are we? And where are we going?

GE Hayes, L Novak-Frazer - Journal of Fungi, 2016 - mdpi.com
Chronic pulmonary aspergillosis (CPA) is estimated to affect 3 million people worldwide
making it an under recognised, but significant health problem across the globe, conferring …

The safety of oral antifungals for the treatment of onychomycosis

AK Gupta, S Haas-Neill, M Talukder - Expert opinion on drug safety, 2023 - Taylor & Francis
Introduction Oral antifungals are used for the treatment of moderate-severe onychomycosis.
Terbinafine and itraconazole are approved for onychomycosis treatment in North America; …

C16-Fengycin A affect the growth of Candida albicans by destroying its cell wall and accumulating reactive oxygen species

Y Liu, J Lu, J Sun, X Zhu, L Zhou, Z Lu, Y Lu - Applied Microbiology and …, 2019 - Springer
Candida albicans is the most common clinical pathogenic fungus, which is highly
susceptible to immunodeficiency. Development of novel antifungal agents has become a …

Antifungal resistance in dermatophytes – review of the epidemiology, diagnostic challenges and treatment strategies for managing Trichophyton indotineae infections

AK Gupta, T Wang, A Mann, S Polla Ravi… - Expert Review of Anti …, 2024 - Taylor & Francis
Introduction There is an increasing number of reports of Trichophyton indotineae infections.
This species is usually poorly responsive to terbinafine. Areas covered A literature search …

Potential targets for antifungal drug discovery based on growth and virulence in Candida albicans

X Li, Y Hou, L Yue, S Liu, J Du… - Antimicrobial agents and …, 2015 - Am Soc Microbiol
Fungal infections, especially infections caused by Candida albicans, remain a challenging
problem in clinical settings. Despite the development of more-effective antifungal drugs, their …

Phytochemicals and their antifungal potential against pathogenic yeasts

C de Andrade Monteiro… - Phytochemicals in human …, 2019 - books.google.com
The rate of fungal infections is increasing rapidly, and pathogenesis of their species is poorly
understood. Among fungi, Candida species are a major cause of morbidity and mortality …

Isavuconazole and voriconazole for the treatment of chronic pulmonary aspergillosis: A retrospective comparison of rates of adverse events

F Bongomin, N Maguire, CB Moore, T Felton… - Mycoses, 2019 - Wiley Online Library
Background Long‐term oral triazole antifungal therapy is the cornerstone of management for
patients with chronic pulmonary aspergillosis (CPA). Itraconazole is the first‐line choice of …