Abstract Interferon Regulatory Factors (IRFs), a family of transcription factors, profoundly
influence the immune system, impacting both physiological and pathological processes …

Pancreatic ductal adenocarcinoma (PDAC) is clinically challenging due to late diagnosis
and resistance to therapy. Two major PDAC subtypes have been defined based on …

The contribution of CD4+ T cells to protective or pathogenic immune responses to SARS-
CoV-2 infection remains unknown. Here, we present single-cell transcriptomic analysis of> …

Summary Relatlimab (rela; anti-LAG-3) plus nivolumab (nivo; anti-PD-1) is safe and effective
for treatment of advanced melanoma. We designed a trial (NCT03743766) where advanced …

The contribution of CD4+ T cells to protective or pathogenic immune responses to SARS-
CoV-2 infection remains unknown. Here, we present large-scale single-cell transcriptomic …

Deep convolutional neural networks (CNNs) trained on regulatory genomic sequences tend
to build representations in a distributed manner, making it a challenge to extract learned …

Transforming growth factor β (TGF-β) increases epithelial cancer cell migration and
metastasis by inducing epithelial-mesenchymal transition (EMT). TGF-β also inhibits cell …

The urothelium is a stratified epithelium composed of basal cells, one or more layers of
intermediate cells, and an upper layer of differentiated umbrella cells. Most bladder cancers …

Interferon-gamma (IFN-γ) has been identified as a crucial factor in determining the
responsiveness to immunotherapy. Produced primarily by natural killer (NK) and T cells, IFN …

Animal studies have demonstrated the ability of pancreatic acinar cells to transform into
pancreatic ductal adenocarcinoma (PDAC). However, the tumorigenic potential of human …