Curcumin analogues and their hybrid molecules as multifunctional drugs

SA Noureddin, RM El-Shishtawy, KO Al-Footy - European journal of …, 2019 - Elsevier
Abstract Curcumin (diferuloylmethane or 1, 7-bis (4-hydroxy-3-methoxyphenyl)-1, 6-
heptadiene-3, 5-dione) is an interesting compound that is characterized by a special …

Curcuma longa and curcumin affect respiratory and allergic disorders, experimental and clinical evidence: A comprehensive and updated review

A Memarzia, S Saadat, S Behrouz, MH Boskabady - Biofactors, 2022 - Wiley Online Library
Curcuma longa and its constituents, mainly curcumin, showed various of pharmacological
effects in previous studies. This review article provides updated and comprehensive …

Anti-inflammatory effects of curcumin are associated with down regulating microRNA-155 in LPS-treated macrophages and mice

F Ma, F Liu, L Ding, M You, H Yue, Y Zhou… - Pharmaceutical …, 2017 - Taylor & Francis
Context: The natural polyphenolic compound curcumin has been proved to modulate innate
immune responses and possess anti-inflammatory properties. Nevertheless, the mechanism …

An overview of structure–activity relationship studies of curcumin analogs as antioxidant and anti-inflammatory agents

L Arshad, MA Haque, SN Abbas Bukhari… - Future medicinal …, 2017 - Taylor & Francis
Curcumin, extracted mainly from Curcuma longa rhizomes, has been reported to possess
potent anti-inflammatory and anti-oxidant activities. Although safe at higher doses and …

Transport of curcumin derivatives in Caco-2 cell monolayers

Z Zeng, ZL Shen, S Zhai, JL Xu, H Liang, Q Shen… - European Journal of …, 2017 - Elsevier
Curcumin (Cur) is a strong natural antioxidant, who can prevent multiple diseases such as
anti-cancer, anti-inflammatory, have a resistance to alzheimer's disease and various …

Phenolic acid profiling, antioxidant, and anti-inflammatory activities, and miRNA regulation in the polyphenols of 16 blueberry samples from China

X Su, J Zhang, H Wang, J Xu, J He, L Liu, T Zhang… - Molecules, 2017 - mdpi.com
To investigate the anti-atherosclerosis related mechanism of blueberries, the phenolic acids
(PAs) content, antioxidant and anti-inflammatory activities, as well as the microRNA (miRNA) …

Dissymmetric pyridyl-substituted 3, 5-bis (arylidene)-4-piperidones as anti-hepatoma agents by inhibiting NF-κB pathway activation

BR Yao, Y Sun, SL Chen, HD Suo, YL Zhang… - European Journal of …, 2019 - Elsevier
To get new anti-hepatoma agents with anti-inflammatory activity and hypotoxicity, a series of
dissymmetric pyridyl-substituted 3, 5-bis (arylidene)-4-piperidones (BAPs, 25–82) were …

Novel dissymmetric 3, 5-bis (arylidene)-4-piperidones as potential antitumor agents with biological evaluation in vitro and in vivo

N Li, WY Xin, BR Yao, CH Wang, W Cong… - European Journal of …, 2018 - Elsevier
Abstract Thirty-five novel dissymmetric 3, 5-bis (arylidene)-4-piperidone derivatives (BAPs,
6a-h, 7a-h, 8a-g, 9a-g, 10a-e) were synthesized and evaluated the cytotoxicity. BAPs 6d, 7h …

Insights on the synthesis of asymmetric curcumin derivatives and their biological activities

PY Khor, MFFM Aluwi, K Rullah, KW Lam - European journal of medicinal …, 2019 - Elsevier
Curcumin is a small organic molecule with pleiotropic biological activities. However, its
multiple structural-pharmacokinetic challenges prevent its development into a clinical drug …

[HTML][HTML] The protective effect of the flavonoid fraction of Abutilon theophrasti Medic. leaves on LPS-induced acute lung injury in mice via the NF-κB and MAPK …

C Tian, P Zhang, J Yang, Z Zhang, H Wang… - Biomedicine & …, 2019 - Elsevier
Accompanied by the damages of epithelial and capillary endothelial cell, acute lung injury is
diagnosed with the typical pathological symptoms in clinic, including diffusing of pulmonary …