Currently, obesity has become a global health issue and is referred to as an epidemic.
Dysfunctional obese adipose tissue plays a pivotal role in the development of insulin …

Obesity is a major risk factor for the development of insulin resistance and type 2 diabetes.
The exact mechanism by which adipose tissue induces insulin resistance is still unclear. It …

Endogenous bioactive lipids are part of a complex network that modulates a plethora of
cellular and molecular processes involved in health and disease, of which inflammation …

Resistance to insulin is a pathophysiological state related to the decreased response of
peripheral tissues to the insulin action, hyperinsulinemia and raised blood glucose levels …

The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …

Excessive accumulation of lipids can lead to lipotoxicity, cell dysfunction and alteration in
metabolic pathways, both in adipose tissue and peripheral organs, like liver, heart, pancreas …

The antioxidant tempol reduces obesity in mice. Here we show that tempol alters the gut
microbiome by preferentially reducing the genus Lactobacillus and its bile salt hydrolase …

Obesity is characterized by a state of chronic, low-grade inflammation. However, excessive
fatty acid release may worsen adipose tissue inflammation and contributes to insulin …

Adipose extracellular vesicles (AdEVs) transport lipids that could participate in the
development of obesity-related metabolic dysfunctions. This study aims to define mouse …

Sphingolipids are structurally and functionally diverse molecules with significant physiologic
functions and are found associated with cellular membranes and plasma lipoproteins. The …