Genome sequencing has yielded a plethora of new genes the function of which can be
unravelled through comparative genomic approaches. Increasingly, developmental …

Three embryonic tissue sources—the neural ectoderm, the surface ectoderm, and the
periocular mesenchyme—contribute to the formation of the mammalian eye. For this reason …

Organogenesis of the eye is a multistep process that starts with the formation of optic
vesicles followed by invagination of the distal domain of the vesicles and the overlying lens …

▪ Abstract This review provides a synthesis that combines data from classical
experimentation and recent advances in our understanding of early eye development …

Several eye-field transcription factors (EFTFs) are expressed in the anterior region of the
vertebrate neural plate and are essential for eye formation. The Xenopus EFTFs ET, Rx1 …

We report here that misexpression of the transcription factor Pax6 in the vertebrate Xenopus
laevis leads to the formation of differentiated ectopic eyes. Multiple molecular markers …

Multipotent retinal progenitors undergo a varied number of divisions to produce clones of
heterogeneous sizes and cell types. We describe the transition from a proliferating …

For a long time, it has been understood that neurogenesis is linked to proliferation and thus
to the cell cycle. Recently, the gears that mediate this linkage have become accessible to …

Uncovering the molecular mechanisms of eye development is crucial for understanding the
embryonic morphogenesis of complex structures, as well as for the establishment of novel …

The telencephalic vesicles are paired evaginations of approaches, particularly in mice and
zebrafish, are rapthe anterior forebrain that constitute the most complex idly identifying …