Epigenetics, fragmentomics, and topology of cell-free DNA in liquid biopsies
BACKGROUND Liquid biopsies that are based on analysis of cell-free DNA from plasma
offer diagnostic information that is otherwise accessible conventionally through invasive …
offer diagnostic information that is otherwise accessible conventionally through invasive …
Clinical relevance of blood-based ctDNA analysis: mutation detection and beyond
Cell-free DNA (cfDNA) derived from tumours is present in the plasma of cancer patients. The
majority of currently available studies on the use of this circulating tumour DNA (ctDNA) deal …
majority of currently available studies on the use of this circulating tumour DNA (ctDNA) deal …
Inferring gene expression from cell-free DNA fragmentation profiles
Profiling of circulating tumor DNA (ctDNA) in the bloodstream shows promise for
noninvasive cancer detection. Chromatin fragmentation features have previously been …
noninvasive cancer detection. Chromatin fragmentation features have previously been …
Genome-wide cell-free DNA fragmentation in patients with cancer
Cell-free DNA in the blood provides a non-invasive diagnostic avenue for patients with
cancer. However, characteristics of the origins and molecular features of cell-free DNA are …
cancer. However, characteristics of the origins and molecular features of cell-free DNA are …
Life and death of circulating cell-free DNA
A Kustanovich, R Schwartz, T Peretz… - Cancer biology & …, 2019 - Taylor & Francis
Tumor-specific, circulating cell-free DNA in liquid biopsies is a promising source of
biomarkers for minimally invasive serial monitoring of treatment responses in cancer …
biomarkers for minimally invasive serial monitoring of treatment responses in cancer …
Bridging biological cfDNA features and machine learning approaches
T Moser, S Kühberger, I Lazzeri, G Vlachos, E Heitzer - Trends in Genetics, 2023 - cell.com
Liquid biopsies (LBs), particularly using circulating tumor DNA (ctDNA), are expected to
revolutionize precision oncology and blood-based cancer screening. Recent technological …
revolutionize precision oncology and blood-based cancer screening. Recent technological …
Multimodal analysis of cell-free DNA whole-genome sequencing for pediatric cancers with low mutational burden
Sequencing of cell-free DNA in the blood of cancer patients (liquid biopsy) provides
attractive opportunities for early diagnosis, assessment of treatment response, and minimally …
attractive opportunities for early diagnosis, assessment of treatment response, and minimally …
Toward the early detection of cancer by decoding the epigenetic and environmental fingerprints of cell-free DNA
Y Van Der Pol, F Mouliere - Cancer cell, 2019 - cell.com
Widespread adaptation of liquid biopsy for the early detection of cancer has yet to reach
clinical utility. Circulating tumor DNA is commonly detected though the presence of genetic …
clinical utility. Circulating tumor DNA is commonly detected though the presence of genetic …
A clinician's handbook for using ctDNA throughout the patient journey
SO Hasenleithner, MR Speicher - Molecular cancer, 2022 - Springer
Background The promise of precision cancer medicine presently centers around the
genomic sequence of a patient's tumor being translated into timely, actionable information to …
genomic sequence of a patient's tumor being translated into timely, actionable information to …
Plasma DNA end-motif profiling as a fragmentomic marker in cancer, pregnancy, and transplantation
Plasma DNA fragmentomics is an emerging area of research covering plasma DNA sizes,
end points, and nucleosome footprints. In the present study, we found a significant increase …
end points, and nucleosome footprints. In the present study, we found a significant increase …