PIP5K-driven PtdIns(4,5)P2 synthesis: regulation and cellular functions
I Van den Bout, N Divecha - Journal of cell science, 2009 - journals.biologists.com
It has long been known that phosphoinositides are present in cellular membranes, but only
in the past four decades has our understanding of their importance for proper cell function …
in the past four decades has our understanding of their importance for proper cell function …
One lipid, multiple functions: how various pools of PI(4,5)P2 are created in the plasma membrane
K Kwiatkowska - Cellular and molecular life sciences, 2010 - Springer
Abstract Phosphatidylinositol 4, 5-bisphosphate [PI (4, 5) P 2] is a minor lipid of the inner
leaflet of the plasma membrane that controls the activity of numerous proteins and serves as …
leaflet of the plasma membrane that controls the activity of numerous proteins and serves as …
Phagocytosis: hungry, hungry cells
M Gray, RJ Botelho - Phagocytosis and Phagosomes: Methods and …, 2017 - Springer
Phagocytosis is the cellular internalization and sequestration of particulate matter into
aphagosome, which then matures into a phagolysosome. The phagolysosome then offers a …
aphagosome, which then matures into a phagolysosome. The phagolysosome then offers a …
Control of diverse subcellular processes by a single multi-functional lipid phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2]
Phosphatidylinositol 4, 5-bisphosphate [PI (4, 5) P 2] is a multi-functional lipid that regulates
several essential subcellular processes in eukaryotic cells. In addition to its well-established …
several essential subcellular processes in eukaryotic cells. In addition to its well-established …
Phosphatidylinositol 4, 5 bisphosphate and the actin cytoskeleton
L Zhang, YS Mao, PA Janmey, HL Yin - Phosphoinositides II: The diverse …, 2012 - Springer
Dynamic changes in PM PIP 2 have been implicated in the regulation of many processes
that are dependent on actin polymerization and remodeling. PIP 2 is synthesized primarily …
that are dependent on actin polymerization and remodeling. PIP 2 is synthesized primarily …
Lipopolysaccharide upregulates palmitoylated enzymes of the phosphatidylinositol cycle: an insight from proteomic studies
J Sobocińska, P Roszczenko-Jasińska… - Molecular & Cellular …, 2018 - ASBMB
Lipopolysaccharide (LPS) is a component of the outer membrane of Gram-negative bacteria
that induces strong proinflammatory reactions of mammals. These processes are triggered …
that induces strong proinflammatory reactions of mammals. These processes are triggered …
The role of PIP5K1A in cancer development and progression
M Yin, Y Wang - Medical Oncology, 2022 - Springer
Malignant tumors are formed via a pathological process of uncontrolled cell division that
seriously endangers human physical and mental health. The PI3K/AKT signaling pathway …
seriously endangers human physical and mental health. The PI3K/AKT signaling pathway …
LPS induces phosphorylation of actin‐regulatory proteins leading to actin reassembly and macrophage motility
Upon bacterial infection lipopolysaccharide (LPS) induces migration of monocytes/
macrophages to the invaded region and production of pro‐inflammatory mediators. We …
macrophages to the invaded region and production of pro‐inflammatory mediators. We …
LPS-induced clustering of CD14 triggers generation of PI(4,5)P2
A Płóciennikowska, MI Zdioruk… - Journal of cell …, 2015 - journals.biologists.com
Bacterial lipopolysaccharide (LPS) induces strong pro-inflammatory reactions after
sequential binding to CD14 protein and TLR4 receptor. Here, we show that CD14 controls …
sequential binding to CD14 protein and TLR4 receptor. Here, we show that CD14 controls …
[HTML][HTML] Sphingomyelin-rich domains are sites of lysenin oligomerization: implications for raft studies
Lysenin is a self-assembling, pore-forming toxin which specifically recognizes
sphingomyelin. Mutation of tryptophan 20 abolishes lysenin oligomerization and cytolytic …
sphingomyelin. Mutation of tryptophan 20 abolishes lysenin oligomerization and cytolytic …