Transposable element (TE)-derived sequences are ubiquitous in most eukaryotic genomes
known to date. Because their expression and mobility can lead to genomic instability …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

Small open reading frames (sORFs) can encode functional" microproteins" that perform
crucial biological tasks. However, their size makes them less amenable to genomic analysis …

Recent advances in single-cell technologies have led to the discovery of thousands of brain
cell types; however, our understanding of the gene regulatory programs in these cell types is …

Aging, often considered a result of random cellular damage, can be accurately estimated
using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we …

Understanding the regulatory landscape of the human genome is a long-standing objective
of modern biology. Using the reference-free alignment across 241 mammalian genomes …

Enhancers are genomic DNA elements controlling spatiotemporal gene expression. Their
flexible organization and functional redundancies make deciphering their sequence-function …

INTRODUCTION The cerebellum contributes to many complex brain functions, including
motor control, language, and memory. During development, distinct neural cells are …

Genomics encompasses the entire tree of life, both extinct and extant, and the evolutionary
processes that shape this diversity. To date, genomic research has focused on humans, a …

During recent years combining GLP-1 and glucagon receptor agonism with the purpose of
achieving superior weight loss and metabolic control compared to GLP-1 alone has …