Alzheimer's drug PBT2 interacts with the amyloid β 1–42 peptide differently than other 8-hydroxyquinoline chelating drugs

KL Summers, G Roseman, KM Schilling… - Inorganic …, 2022 - ACS Publications
Although Alzheimer's disease (AD) was first described over a century ago, it remains the
leading cause of age-related dementia. Innumerable changes have been linked to the …

A mass spectrometric approach to study the interaction of amyloid β peptides with human α-2-macroglobulin

AV Protasov, OA Mirgorodskaya, YP Kozmin, J Gobom - Biochimie, 2021 - Elsevier
We used MALDI-MS to study the interaction of amyloid β (Aβ) peptides with alpha-2-
macroglobulin (α2M). The binding of amyloid beta (Aβ) peptides to alpha-2-macroglobulin …

Molecular mechanism of the inhibition of TDP-43 amyloidogenesis by QBP1

M Mompean, DR de Mingo, R Hervas… - Archives of biochemistry …, 2019 - Elsevier
Abstract Transactive Response DNA-Binding Protein of 43 kDa (TDP-43) is an essential
human protein implicated in Amyotrophic Lateral Sclerosis (ALS) and common dementias …

The Effect of Ethanol on Disassembly of Amyloid-β1-42 Pentamer Revealed by Atomic Force Microscopy and Gel Electrophoresis

A Matsui, JP Bellier, T Kanai, H Satooka… - International journal of …, 2022 - mdpi.com
The most common type of dementia, Alzheimer's disease, is associated with senile plaques
formed by the filamentous aggregation of hydrophobic amyloid-β (Aβ) in the brains of …

Complex system assembly underlies a two-tiered model of highly delocalized electrons

M Mompean, A Nogales, TA Ezquerra… - The journal of physical …, 2016 - ACS Publications
Amyloid fibrils are exceptionally stable oligomeric structures with extensive, highly
cooperative H-bonding networks whose physical origin remains elusive. While nonpolar …

Solvation of 2-(hydroxymethyl)-2, 5, 7, 8-tetramethyl-chroman-6-ol revealed by circular dichroism: a case of chromane helicity rule breaking

JE Rode, M Górecki, S Witkowski… - Physical Chemistry …, 2018 - pubs.rsc.org
The primary goal of this work is to clarify why 2-(hydroxymethyl)-2, 5, 7, 8-tetramethyl-
chroman-6-ol {(S)-TMChM} deviates from the chromane helicity rule under solvent change …

A pyrene-inhibitor fluorescent probe with large Stokes shift for the staining of Aβ 1–42, α-synuclein, and amylin amyloid fibrils as well as amyloid-containing …

A Mahía, M Conde-Giménez, S Salillas… - Analytical and …, 2019 - Springer
Amyloid fibrils formed by a variety of peptides are biological markers of different human
diseases, such as Alzheimer's disease, Parkinson's disease, and type II diabetes, and are …

Учредители: Институт аналитического приборостроения РАН, Российская академия наук

П НАУЧНОЕ - НАУЧНОЕ ПРИБОРОСТРОЕНИЕ, 2022 - elibrary.ru
В данной работе представлен краткий обзор современных тенденций в развитии
технологий изготовления сенсоров довзрывоопасных концентраций горючих газов и …

[HTML][HTML] ОСОБЕННОСТИ МАСС-СПЕКТРОМЕТРИЧЕСКОЙ ДЕТЕКЦИИ БЕТА-АМИЛОИДНЫХ ПЕПТИДОВ (ПЕПТИДОВ АЛЬЦГЕЙМЕРА)

ОА Миргородская, АВ Протасов… - Научное …, 2022 - cyberleninka.ru
Масс-спектрометрия в сочетании с использованием изотопно-меченных стандартов
является одним из популярных методов количественного измерения концентрации …

A pyrene-inhibitor fluorescent probe with large Stokes shift for the staining of Aß1-42, a-synuclein, and amylin amyloid fibrils as well as amyloid-containing …

A Mahía, J Sancho, M Conde-Giménez, S Salillas… - 2019 - zaguan.unizar.es
Amyloid fibrils formed by a variety of peptides are biological markers of different human
diseases, such as Alzheimer's disease, Parkinson's disease, and type II diabetes, and are …