Fatty acids are essential for survival, acting as bioenergetic substrates, structural
components and signalling molecules. Given their vital role, cells have evolved mechanisms …

Cancer cells alter metabolic processes to sustain their characteristic uncontrolled growth
and proliferation. These metabolic alterations include (1) a shift from oxidative …

Tumors undergo metabolic transformations to sustain uncontrolled proliferation, avoid cell
death, and seed in secondary organs. An increased focus on cancer lipid metabolism has …

Aberrant metabolism is a major hallmark of cancer. Abnormal cancer metabolism, such as
aerobic glycolysis and increased anabolic pathways, has important roles in tumorigenesis …

With the advent of effective tools to study lipids, including mass spectrometry-based
lipidomics, lipids are emerging as central players in cancer biology. Lipids function as …

Lipid metabolic reprogramming is an emerging hallmark of cancer. In order to sustain
uncontrolled proliferation and survive in unfavorable environments that lack oxygen and …

Vendor-independent software tools for quantification of small molecules and metabolites are
lacking, especially for targeted analysis workflows. Skyline is a freely available, open-source …

Cancer remains the second leading cause of mortality worldwide. In the course of this
multistage and multifactorial disease, a set of alterations takes place, with genetic and …

Different lifestyles have an impact on useful metabolic functions, causing disorders. Different
lipids are involved in the metabolic functions that play various vital roles in the body, such as …

A hallmark of prostate cancer progression is dysregulation of lipid metabolism via
overexpression of fatty acid synthase (FASN), a key enzyme in de novo fatty acid synthesis …