Challenges and future trends in the treatment of psoriasis

HJ Lee, M Kim - International Journal of Molecular Sciences, 2023 - mdpi.com
Psoriasis is a chronic inflammatory skin disorder, and current treatments include topical
therapies, phototherapy, systemic immune modulators, and biologics, aiming to alleviate …

Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with biologics

A Menter, BE Strober, DH Kaplan, D Kivelevitch… - Journal of the American …, 2019 - Elsevier
Psoriasis is a chronic, inflammatory multisystem disease that affects up to 3.2% of the US
population. This guideline addresses important clinical questions that arise in psoriasis …

EuroGuiDerm Guideline on the systemic treatment of Psoriasis vulgaris–Part 1: treatment and monitoring recommendations

A Nast, C Smith, PI Spuls, G Avila Valle… - Journal of the …, 2020 - Wiley Online Library
This evidence‐and consensus‐based guideline on the treatment of psoriasis vulgaris was
developed following the EuroGuiDerm Guideline and Consensus Statement Development …

Ustekinumab for type 1 diabetes in adolescents: a multicenter, double-blind, randomized phase 2 trial

D Tatovic, A Marwaha, P Taylor, SJ Hanna, K Carter… - Nature Medicine, 2024 - nature.com
Immunotherapy targeting the autoimmune process in type 1 diabetes (T1D) can delay the
loss of β-cells but needs to have minimal adverse effects to be an adjunct to insulin in the …

[HTML][HTML] Focus: skin: current developments in the immunology of psoriasis

F Grän, A Kerstan, E Serfling, M Goebeler… - The Yale journal of …, 2020 - ncbi.nlm.nih.gov
Psoriasis is a frequent inflammatory skin disease. Fundamental research on the
pathogenesis of psoriasis has substantially increased our understanding of skin …

Systematic review and network meta‐analysis: first‐and second‐line biologic therapies for moderate‐severe Crohn's disease

S Singh, M Fumery, WJ Sandborn… - Alimentary …, 2018 - Wiley Online Library
Background There are limited data to inform positioning of agents for treating moderate‐
severe Crohn's disease (CD). Aim We assessed comparative efficacy and safety of first‐line …

Association between biologics use and risk of serious infection in patients with psoriasis

L Penso, R Dray-Spira, A Weill, LP Vegas… - JAMA …, 2021 - jamanetwork.com
Importance Biologics and targeted therapies, such as apremilast, are efficient treatments to
manage moderate to severe psoriasis. More information about the risk of serious infection is …

Long-term safety of oral systemic therapies for psoriasis: a comprehensive review of the literature

DMW Balak, S Gerdes, A Parodi… - Dermatology and …, 2020 - Springer
Oral systemic therapies are important treatment options for patients with moderate-to-severe
psoriasis, either as monotherapy or in therapy-recalcitrant cases as combination therapy …

Long-term safety of adalimumab in 29,967 adult patients from global clinical trials across multiple indications: an updated analysis

GR Burmester, KB Gordon, JT Rosenbaum… - Advances in …, 2020 - Springer
Introduction The safety profile of adalimumab was previously reported in 23,458 patients
across multiple indications. Here we report the long-term safety of adalimumab in adults with …

Differential efficacy of biologic treatments targeting the TNF-α/IL-23/IL-17 axis in psoriasis and psoriatic arthritis

K Furue, T Ito, M Furue - Cytokine, 2018 - Elsevier
Psoriasis and psoriatic arthritis cause significant physical and psychological burdens for
afflicted individuals. An accelerated TNF-α/IL-23/IL-17 axis is their major pathomechanism; …