Abstract Model-informed precision dosing (MIPD) stands as a significant development in
personalized medicine to tailor drug dosing to individual patient characteristics. MIPD moves …

Computational oncology is a generic term that encompasses any form of computer-based
modelling relating to tumour biology and cancer therapy. Mathematical modelling can be …

Updated with new chapters and topics, this book provides a comprehensive description of
all essential topics in contemporary pharmacokinetics and pharmacodynamics. It also …

Aims This study aims to assess approaches to handle interoccasion variability (IOV) in a
model‐based therapeutic drug monitoring (TDM) context, using a population …

Despite advances in biomedical research that have deepened our understanding of cancer
hallmarks, resulting in the discovery and development of targeted therapies, the success …

In oncology trials, overall survival (OS) is considered the most reliable and preferred
endpoint to evaluate the benefit of drug treatment. Other relevant variables are also …

Abstract Model‐informed precision dosing (MIPD) using therapeutic drug/biomarker
monitoring offers the opportunity to significantly improve the efficacy and safety of drug …

Purpose Neutropenia is a severe adverse-event of chemotherapeutics. Neutrophils (ANC)
are mainly regulated by granulocyte colony stimulating factor (G-CSF). The aim was to …

Despite its great promise, personalized oncology still faces many hurdles, and it is
increasingly clear that targeted drugs and molecular biomarkers alone yield only modest …

Introduction At tamoxifen standard dosing,∼ 20% of breast cancer patients do not reach
proposed target endoxifen concentrations> 5.97 ng/mL. Thus, better understanding the large …