Since its discovery, the study of the biological role of α-synuclein and its pathological
implications has been the subject of increasing interest. The propensity to adopt different …

Atomic force microscopy is an increasingly attractive tool to study how peptides disrupt
membranes. Often performed on reconstituted lipid bilayers, it provides access to time and …

α-synuclein (αS) is an intrinsically disordered protein whose functional ambivalence and
protein structural plasticity are iconic. Coordinated protein recruitment ensures proper …

Amphipathic styrene-maleic acid (SMA) copolymers directly solubilize biomembranes into
SMA-lipid particles, or SMALPs, that are often regarded as nanodiscs and hailed as a native …

Polyanionic lipopolysaccharides (LPS) play an important role in regulating the permeability
of the outer membrane (OM) of Gram-negative bacteria. Impairment of the LPS-enriched OM …

Disruption of cell membranes is a fundamental host defense response found in virtually all
forms of life. The molecular mechanisms vary but generally lead to energetically favored …

Alpha-Synuclein (AS) is the protein playing the major role in Parkinson's disease (PD), a
neurological disorder characterized by the degeneration of dopaminergic neurons and the …

α-Synuclein (αS) is a presynaptic protein whose aggregation is associated with Parkinson's
disease (PD). Although the physiological function of αS is still unclear, several lines of …

Pro-inflammatory, calcium-binding protein S100A9 is localized in the cytoplasm of many
cells and regulates several intracellular and extracellular processes. S100A9 is involved in …

The SARS-CoV-2 E protein is an enigmatic viral structural protein with reported viroporin
activity associated with the acute respiratory symptoms of COVID-19, as well as the ability to …