Abstract Disrupted-in-Schizophrenia 1 (DISC1) is a gene known as a risk factor for mental
illnesses possibly associated with dopamine impairments. DISC1 is a scaffold protein …

Background: Schizophrenia is a serious mental illness that affects more than 21 million
people worldwide. Both genetics and the environment play a role in its etiology and …

Neurons populating the cerebral cortex are generated during embryonic development from
neural stem and progenitor cells in a process called neurogenesis. Neural stem and …

Dopamine-glutamate interplay dysfunctions have been suggested as pathophysiological
key determinants of major psychotic disorders, above all schizophrenia and mood disorders …

Mice are widely used to model wide-ranging human neurological disorders, from
development to degenerative pathophysiology. Behavioural and molecular characteristics of …

Abstract Disrupted in schizophrenia 1 (DISC1) is a multi-functional scaffolding protein that
has been associated with neuropsychiatric disease. The role of DISC1 is to assemble …

Englerin A (EA) is a natural product which has potent cytotoxic effects on renal cell
carcinoma cells and other types of cancer cell but not non-cancer cells. Although selectively …

Elevated GSK-3 activity has been implicated in cognitive dysfunction associated with various
disorders including Alzheimer's disease, schizophrenia, type 2 diabetes, traumatic brain …

Synaptic pruning is a critical refinement step during neurodevelopment, and schizophrenia
has been associated with overpruning of cortical dendritic spines. Both human studies and …

We investigated the genome of a 5-year-old male who presented with global developmental
delay (motor, cognitive, and speech), hypotonia, possibly ataxia, and cerebellar hypoplasia …