Baeyer–Villiger monooxygenases: tunable oxidative biocatalysts

MJLJ Fürst, A Gran-Scheuch, FS Aalbers… - ACS …, 2019 - ACS Publications
Pollution, accidents, and misinformation have earned the pharmaceutical and chemical
industry a poor public reputation, despite their undisputable importance to society …

Sulfoxide reductases and applications in biocatalytic preparation of chiral sulfoxides: a mini-review

T Peng, X Cheng, Y Chen, J Yang - Frontiers in Chemistry, 2021 - frontiersin.org
Chiral sulfoxides are valuable organosulfur compounds that have been widely used in
medicinal and organic synthesis. Biocatalytic approaches for preparing chiral sulfoxides …

A Baeyer-Villiger monooxygenase from Cupriavidus basilensis catalyzes asymmetric synthesis of (R)-lansoprazole and other pharmaco-sulfoxides

F Liu, C Shou, Q Geng, C Zhao, J Xu, H Yu - Applied Microbiology and …, 2021 - Springer
Biocatalytic synthesis of pharmaco-chiral sulfoxides has gained interest in recent years for
its environmental friendliness. However, only a few natural biocatalysts can be used for the …

Accessing Enantiopure Epoxides and Sulfoxides: Related Flavin‐Dependent Monooxygenases Provide Reversed Enantioselectivity

T Heine, A Scholtissek, S Hofmann, R Koch… - …, 2020 - Wiley Online Library
Enantiopure organic compounds are of major importance for the chemical and
pharmaceutical industry. Flavin‐dependent group E monooxygenases, composed of …

Kinetic resolution of sulfoxides with high enantioselectivity using a new homologue of methionine sulfoxide reductase B

Y Zhao, X Jiang, S Zhou, J Tian, P Yang… - Organic & …, 2023 - pubs.rsc.org
Optically pure sulfoxides are noteworthy compounds that find wide applications in various
industrial fields. Here, we report a methionine sulfoxide reductase B (MsrB) homologue that …

Discovery and Rational Mutagenesis of Methionine Sulfoxide Reductase Biocatalysts To Expand the Substrate Scope of the Kinetic Resolution of Chiral Sulfoxides

S Anselmi, ATP Carvalho, A Serrano-Sanchez… - ACS …, 2023 - ACS Publications
Methionine sulfoxide reductase A (MsrA) enzymes have recently found applications as
nonoxidative biocatalysts in the enantioselective kinetic resolution of racemic sulfoxides …

[HTML][HTML] What to sacrifice? Fusions of cofactor regenerating enzymes with Baeyer-Villiger monooxygenases and alcohol dehydrogenases for self-sufficient redox …

Á Mourelle-Insua, FS Aalbers, I Lavandera… - Tetrahedron, 2019 - Elsevier
A collection of fusion biocatalysts has been generated that can be used for self-sufficient
oxygenations or ketone reductions. These biocatalysts were created by fusing a Baeyer …

Enzymatic synthesis of pharmacologically relevant chiral sulfoxides by improved Cb BVMO variants

C Zhao, F Liu, M Zhou, Q Geng, HL Yu - Chemical Communications, 2023 - pubs.rsc.org
Baeyer–Villiger monooxygenases (BVMOs) are able to catalyse the asymmetric oxidation of
sulfides. This property has made them attractive catalysts for the synthesis of chiral sulfoxide …

Baeyer-Villiger monooxygenases: From protein engineering to biocatalytic applications

S Schmidt, UT Bornscheuer - The Enzymes, 2020 - Elsevier
Biocatalytic processes are well established for the synthesis of high-value fine chemicals,
especially for chiral pharmaceutical intermediates, by using natural or engineered enzymes …

Enantioselective sulfoxidations employing the thermostable cyclohexanone monooxygenase from Thermocrispum municipale

G de Gonzalo, A Franconetti - Enzyme and microbial technology, 2018 - Elsevier
The recently discovered cyclohexanone monooxygenase from Thermocrispum municipale
(TmCHMO) was employed in the preparation of different optically active sulfoxides. This …