Protein design is a valuable tool for understanding the fundamental factors that dictate
protein structure and function. The field of protein design has seen significant progress over …

Specific interactions between proteins and DNA are fundamental to many biological
processes. In this review, we provide a revised view of protein-DNA interactions that …

The transition or d-block metal ions manganese, iron, cobalt, nickel, copper, zinc and to a
more specialized degree molybdenum, tungsten, and vanadium have been shown to be …

On the basis of a structural analysis of 240 protein-DNA complexes contained in the Protein
Data Bank (PDB), we have classified the DNA-binding proteins involved into eight different …

The Smad family of proteins, which are frequently targeted by tumorigenic mutations in
cancer, mediate TGF-β signaling from cell membrane to nucleus. The crystal structure of a …

The 3D solution structure of the GCC‐box binding domain of a protein from Arabidopsis
thaliana in complex with its target DNA fragment has been determined by heteronuclear …

The nuclear hormone receptors are a superfamily of ligand-activated DNA-binding
transcription factors. We have determined the crystal structure (at 2.4 A) of the fully specific …

Bacterial conjugation results in the transfer of DNA of either plasmid or chromosomal origin
between microorganisms. Transfer begins at a defined point in the DNA sequence, usually …

DNA gyrase is a type II DNA topoisomerase from bacteria that introduces supercoils into
DNA,. It catalyses the breakage of a DNA duplex (the G segment), the passage of another …

Proteins that recognize specific DNA sequences play a central role in the regulation of
transcription. The tremendous increase in structural information on protein-DNA complexes …