The Genetic Variability of APOE in Different Human Populations and Its Implications for Longevity
Human longevity is a complex phenotype resulting from the combinations of context-
dependent gene-environment interactions that require analysis as a dynamic process in a …
dependent gene-environment interactions that require analysis as a dynamic process in a …
Genetics of human longevity within an eco-evolutionary nature-nurture framework
Human longevity is a complex trait, and to disentangle its basis has a great theoretical and
practical consequences for biomedicine. The genetics of human longevity is still poorly …
practical consequences for biomedicine. The genetics of human longevity is still poorly …
The origin and legacy of the Etruscans through a 2000-year archeogenomic time transect
The origin, development, and legacy of the enigmatic Etruscan civilization from the central
region of the Italian peninsula known as Etruria have been debated for centuries. Here we …
region of the Italian peninsula known as Etruria have been debated for centuries. Here we …
Whole-genome sequencing analysis of semi-supercentenarians
P Garagnani, J Marquis, M Delledonne, C Pirazzini… - Elife, 2021 - elifesciences.org
Extreme longevity is the paradigm of healthy aging as individuals who reached the extreme
decades of human life avoided or largely postponed all major age-related diseases. In this …
decades of human life avoided or largely postponed all major age-related diseases. In this …
Genomic signatures of high-altitude adaptation in Ethiopian sheep populations
Background Ethiopian sheep populations such as Arsi-Bale, Horro and Adilo (long fat-tailed,
LFT) inhabit mid to high-altitude areas; and Menz sheep (MZ, short fat-tailed) are adapted to …
LFT) inhabit mid to high-altitude areas; and Menz sheep (MZ, short fat-tailed) are adapted to …
Population structure of modern-day Italians reveals patterns of ancient and archaic ancestries in Southern Europe
European populations display low genetic differentiation as the result of long-term blending
of their ancient founding ancestries. However, it is unclear how the combination of ancient …
of their ancient founding ancestries. However, it is unclear how the combination of ancient …
Ancient and recent admixture layers in Sicily and Southern Italy trace multiple migration routes along the Mediterranean
The Mediterranean shores stretching between Sicily, Southern Italy and the Southern
Balkans witnessed a long series of migration processes and cultural exchanges …
Balkans witnessed a long series of migration processes and cultural exchanges …
Amyloid precursor protein A713T mutation in Calabrian patients with Alzheimer's Disease: A population genomics approach to estimate inheritance from a common …
Mutation A713T in the amyloid precursor protein (APP) has been linked to cases of
Alzheimer's disease (AD), cerebral amyloid angiopathy (CAA) and cerebrovascular disease …
Alzheimer's disease (AD), cerebral amyloid angiopathy (CAA) and cerebrovascular disease …
A combined targeted and whole exome sequencing approach identified novel candidate genes involved in heritable pulmonary arterial hypertension
C Barozzi, M Galletti, L Tomasi, S De Fanti… - Scientific reports, 2019 - nature.com
The pathogenesis of idiopathic and heritable forms of pulmonary arterial hypertension is still
not completely understood, even though several causative genes have been proposed, so …
not completely understood, even though several causative genes have been proposed, so …
A bird's-eye view of Italian genomic variation through whole-genome sequencing
The genomic variation of the Italian peninsula populations is currently under characterised:
the only Italian whole-genome reference is represented by the Tuscans from the 1000 …
the only Italian whole-genome reference is represented by the Tuscans from the 1000 …