Multiple approaches have been developed to combat bacterial resistance. However, the
combination of antibiotic resistance mechanisms by bacteria and the limited number of …

The rapid increase in pathogenic microorganisms with antimicrobial resistant profiles has
become a significant public health problem globally. The management of this issue using …

Clinically, antibiotics are widely used to treat infectious diseases; however, excessive drug
abuse and overuse exacerbate the prevalence of drug-resistant bacterial pathogens …

Hereunder, we highlight bacterial membrane anionic lipids as attractive targets in the design
of antibacterial drugs which can be effective against both Gram-positive and Gram-negative …

Acinetobacter baumannii (A. baumannii) is a Gram-negative opportunistic pathogen widely
attached to the surface of medical instruments, making it one of the most common pathogens …

Core–shell magnetic nanoparticles (MNPs) are promising candidates in the development of
new treatment methods against infections, including those caused by antibiotic-resistant …

The COVID-19 pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2
(SARS-CoV-2) heavily burdened the entire world socially and economically. Despite a …

Ceragenins (CSAs) are synthetic, lipid-based molecules that display activities of natural
antimicrobial peptides. Previous studies demonstrated their high in vitro activity against …

We recently reported the bioinspired synthesis of a highly potent nonpeptidic xanthone, 2c
(AM-0016), with potent antibacterial activity against MRSA. Herein, we report a thorough …

Ceragenins constitute a novel family of cationic antibiotics characterized by a broad
spectrum of antimicrobial activities, which have mostly been assessed in vitro. Using a …