COVID-19 therapeutics: Challenges and directions for the future

PC Robinson, DFL Liew, HL Tanner… - Proceedings of the …, 2022 - National Acad Sciences
The emergence of SARS-CoV-2 triggering the COVID-19 pandemic ranks as arguably the
greatest medical emergency of the last century. COVID-19 has highlighted health disparities …

Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection

FJ Ryan, CM Hope, MG Masavuli, MA Lynn… - BMC medicine, 2022 - Springer
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly
infectious respiratory virus which is responsible for the coronavirus disease 2019 (COVID …

[HTML][HTML] The interferon landscape along the respiratory tract impacts the severity of COVID-19

B Sposito, A Broggi, L Pandolfi, S Crotta, N Clementi… - Cell, 2021 - cell.com
Summary Severe coronavirus disease 2019 (COVID-19) is characterized by overproduction
of immune mediators, but the role of interferons (IFNs) of the type I (IFN-I) or type III (IFN-III) …

Cellular therapies for the treatment and prevention of SARS-CoV-2 infection

SR Conway, MD Keller… - Blood, The Journal of the …, 2022 - ashpublications.org
Patients with blood disorders who are immune suppressed are at increased risk for infection
with severe acute respiratory syndrome coronavirus 2. Sequelae of infection can include …

Spontaneous, persistent, T cell–dependent IFN-γ release in patients who progress to Long Covid

BA Krishna, EY Lim, M Metaxaki, S Jackson… - Science …, 2024 - science.org
After acute infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a
proportion of patients experience persistent symptoms beyond 12 weeks, termed Long …

An aberrant inflammatory response in severe COVID-19

M Merad, A Subramanian, TT Wang - Cell host & microbe, 2021 - cell.com
Severe COVID-19 arises from the convergence of inadequate pre-existing immunity and a
host response that damages, rather than repairs, tissues. We outline clinical presentations of …

Diffusion and relaxation edited proton NMR spectroscopy of plasma reveals a high-fidelity supramolecular biomarker signature of SARS-CoV-2 infection

S Lodge, P Nitschke, T Kimhofer, J Wist… - Analytical …, 2021 - ACS Publications
We have applied nuclear magnetic resonance spectroscopy based plasma phenotyping to
reveal diagnostic molecular signatures of SARS-CoV-2 infection via combined diffusional …

Multi-omic profiling reveals early immunological indicators for identifying COVID-19 Progressors

KA Drake, D Talantov, GJ Tong, JT Lin, S Verheijden… - Clinical …, 2023 - Elsevier
We sought to better understand the immune response during the immediate post-diagnosis
phase of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by identifying …

[PDF][PDF] Third and fourth vaccine doses broaden and prolong immunity to SARS-CoV-2 in adult patients with immune-mediated inflammatory diseases

MW Cheung, RM Dayam, JR Shapiro… - The Journal of …, 2023 - journals.aai.org
Previous studies have reported impaired humoral responses after SARS-CoV-2 mRNA
vaccination in patients with immune-mediated inflammatory diseases (IMIDs), particularly …

Coronavirus disease 2019–related myocardial injury is associated with immune dysregulation in symptomatic patients with cardiac magnetic resonance imaging …

A Ćorović, X Zhao, Y Huang, SR Newland… - Cardiovascular …, 2024 - academic.oup.com
Aims While acute cardiovascular complications of coronavirus disease 2019 (COVID-19) are
well described, less is known about longer-term cardiac sequelae. For many individuals with …