Tankyrase-targeted therapeutics: expanding opportunities in the PARP family
JL Riffell, CJ Lord, A Ashworth - Nature reviews Drug discovery, 2012 - nature.com
The poly (ADP-ribose) polymerase (PARP) protein superfamily has wide-ranging roles in
cellular processes such as DNA repair and WNT signalling. Efforts to pharmacologically …
cellular processes such as DNA repair and WNT signalling. Efforts to pharmacologically …
PARP1: liaison of chromatin remodeling and transcription
W Zong, Y Gong, W Sun, T Li, ZQ Wang - Cancers, 2022 - mdpi.com
Simple Summary Poly (ADP-ribose) polymerase 1 (PARP1) is perhaps the most studied
member of the PARP superfamily and participates in numerous cellular processes. PARP1 …
member of the PARP superfamily and participates in numerous cellular processes. PARP1 …
[图书][B] Handbook of vitamins
J Zempleni, JW Suttie, JF Gregory III, PJ Stover - 2013 - books.google.com
Within the last few years, knowledge about vitamins has increased dramatically. This new
edition of a bestseller presents comprehensive summaries that analyze the chemical …
edition of a bestseller presents comprehensive summaries that analyze the chemical …
Sirtuin deacylases: a molecular link between metabolism and immunity
N Preyat, O Leo - Journal of leukocyte biology, 2013 - academic.oup.com
Review on the role of sirtuins in modulating an inflammatory response. Lysine deacetylation
by the NAD+-dependent family of sirtuins has been recognized as an important post …
by the NAD+-dependent family of sirtuins has been recognized as an important post …
Neuronal death induced by misfolded prion protein is due to NAD+ depletion and can be relieved in vitro and in vivo by NAD+ replenishment
M Zhou, G Ottenberg, GF Sferrazza, C Hubbs, M Fallahi… - Brain, 2015 - academic.oup.com
The mechanisms of neuronal death in protein misfolding neurodegenerative diseases such
as Alzheimer's, Parkinson's and prion diseases are poorly understood. We used a highly …
as Alzheimer's, Parkinson's and prion diseases are poorly understood. We used a highly …
ARTD10 substrate identification on protein microarrays: regulation of GSK3β by mono-ADP-ribosylation
Background Although ADP-ribosylation has been described five decades ago, only recently
a distinction has been made between eukaryotic intracellular poly-and mono-ADP …
a distinction has been made between eukaryotic intracellular poly-and mono-ADP …
Expanding functions of intracellular resident mono‐ADP‐ribosylation in cell physiology
Poly‐ADP‐ribosylation functions in diverse signaling pathways, such as Wnt signaling and
DNA damage repair, where its role is relatively well characterized. Contrarily, mono‐ADP …
DNA damage repair, where its role is relatively well characterized. Contrarily, mono‐ADP …
PARP7 and mono-ADP-ribosylation negatively regulate estrogen receptor α signaling in human breast cancer cells
M Rasmussen, S Tan, VS Somisetty, D Hutin… - Cells, 2021 - mdpi.com
ADP-ribosylation is a post-translational protein modification catalyzed by a family of proteins
known as poly-ADP-ribose polymerases. PARP7 (TIPARP; ARTD14) is a mono-ADP …
known as poly-ADP-ribose polymerases. PARP7 (TIPARP; ARTD14) is a mono-ADP …
A ribose-functionalized NAD+ with unexpected high activity and selectivity for protein poly-ADP-ribosylation
Abstract Nicotinamide adenine dinucleotide (NAD+)-dependent ADP-ribosylation plays
important roles in physiology and pathophysiology. It has been challenging to study this key …
important roles in physiology and pathophysiology. It has been challenging to study this key …
Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer
JD Steffen, RM Tholey, MF Langelier, JL Planck… - Cancer research, 2014 - AACR
PARP-1 is a nuclear protein that has important roles in maintenance of genomic integrity.
During genotoxic stress, PARP-1 recruits to sites of DNA damage where PARP-1 domain …
During genotoxic stress, PARP-1 recruits to sites of DNA damage where PARP-1 domain …