Muscarinic acetylcholine receptors (mAChRs; M1–M5) play key roles in regulating the
activity of many important functions of the central and peripheral nervous system. Because of …

Cholinergic transmission at muscarinic acetylcholine receptors (mAChR) has been
implicated in higher brain functions such as learning and memory, and loss of synapses may …

Nitric oxide (NO) is a widespread, potent, biological mediator that has many physiological
and pathophysiological roles. Research in the field of NO appears to have followed a …

Schizophrenia is a severe neuropsychiatric disorder characterized by a diverse range of
symptoms that can have profound impacts on the lives of patients. Currently available …

Muscarinic and nicotinic acetylcholine (ACh) receptors (mAChRs and nAChRs) are
emerging as important targets for the development of novel treatments for the symptoms …

Striatal cholinergic interneurons (ChIs) are central for the processing and reinforcement of
reward‐related behaviors that are negatively affected in states of altered dopamine …

Dopaminergic neurons in the substantia nigra pars compacta and ventral tegmental area of
the midbrain form the nigrostriatal and mesocorticolimbic dopaminergic pathways that …

Members of the muscarinic acetylcholine receptor family (M1–M5) have central roles in the
regulation of many fundamental physiological functions,. Identifying the specific receptor …

One of the hallmarks of type 2 diabetes is that pancreatic β cells fail to release sufficient
amounts of insulin in the presence of elevated blood glucose levels. Insulin secretion is …

Muscarinic acetylcholine receptors (mAChRs) are G proteincoupled receptors (GPCRs) that
mediate the metabotropic actions of acetylcholine (ACh). There are five subtypes of mAChR …