Ten things you should know about protein kinases: IUPHAR R eview 14

D Fabbro, SW Cowan‐Jacob… - British journal of …, 2015 - Wiley Online Library
Many human malignancies are associated with aberrant regulation of protein or lipid
kinases due to mutations, chromosomal rearrangements and/or gene amplification. Protein …

Цитокины в патогенезе и лечении заболеваний человека

АС Симбирцев - 2018 - elibrary.ru
В монографии приведены сведения по роли цитокинов в регуляции физиологических
процессов, защитных реакций организма и в патогенезе иммунопатологических …

Induction of microRNA-221 by platelet-derived growth factor signaling is critical for modulation of vascular smooth muscle phenotype

BN Davis, AC Hilyard, PH Nguyen, G Lagna… - Journal of Biological …, 2009 - ASBMB
The platelet-derived growth factor (PDGF) signaling pathway is a critical regulator of animal
development and homeostasis. Activation of the PDGF pathway leads to neointimal …

Gastrointestinal stromal tumor

M Stamatakos, E Douzinas, C Stefanaki… - World Journal of …, 2009 - Springer
Background GISTs are a subset of mesenchymal tumors and represent the most common
mesenchymal neoplasms of GI tract. However, GIST is a recently recognized tumor entity …

Targeting cancer with small-molecular-weight kinase inhibitors

D Fabbro, SW Cowan-Jacob, H Möbitz… - … inhibitors: methods and …, 2012 - Springer
Protein and lipid kinases fulfill essential roles in many signaling pathways that regulate
normal cell functions. Deregulation of these kinase activities lead to a variety of pathologies …

Mucosal melanomas: a case-based review of the literature

N Seetharamu, PA Ott, AC Pavlick - The oncologist, 2010 - academic.oup.com
Abstract Learning Objectives After completing this course, the reader will be able to:
Differentiate mucosal melanoma from cutaneous melanoma and describe its etiology …

Phase I dose-escalation and pharmacokinetic study of dasatinib in patients with advanced solid tumors

GD Demetri, P Lo Russo, IRJ MacPherson… - Clinical Cancer …, 2009 - AACR
Purpose: To determine the maximum tolerated dose, dose-limiting toxicity (DLT), and
recommended phase II dose of dasatinib in metastatic solid tumors refractory to standard …

c-Kit signaling potentiates CAR T cell efficacy in solid tumors by CD28-and IL-2-independent co-stimulation

Y Xiong, M Taleb, K Misawa, Z Hou, S Banerjee… - Nature Cancer, 2023 - nature.com
The limited efficacy of chimeric antigen receptor (CAR) T cell therapy for solid tumors
necessitates engineering strategies that promote functional persistence in an …

[HTML][HTML] Patient-derived scaffolds uncover breast cancer promoting properties of the microenvironment

G Landberg, P Fitzpatrick, P Isakson, E Jonasson… - Biomaterials, 2020 - Elsevier
Tumor cells interact with the microenvironment that specifically supports and promotes tumor
development. Key components in the tumor environment have been linked to various …

[HTML][HTML] Revolutionizing CAR T-Cell Therapies: Innovations in Genetic Engineering and Manufacturing to Enhance Efficacy and Accessibility

L Giorgioni, A Ambrosone, MF Cometa… - International Journal of …, 2024 - mdpi.com
Chimeric antigen receptor (CAR) T-cell therapy has achieved notable success in treating
hematological cancers but faces significant challenges in solid-tumor treatment and overall …