В монографии приведены сведения по роли цитокинов в регуляции физиологических процессов, защитных реакций организма и в патогенезе иммунопатологических …
BN Davis, AC Hilyard, PH Nguyen, G Lagna… - Journal of Biological …, 2009 - ASBMB
The platelet-derived growth factor (PDGF) signaling pathway is a critical regulator of animal development and homeostasis. Activation of the PDGF pathway leads to neointimal …
M Stamatakos, E Douzinas, C Stefanaki… - World Journal of …, 2009 - Springer
Background GISTs are a subset of mesenchymal tumors and represent the most common mesenchymal neoplasms of GI tract. However, GIST is a recently recognized tumor entity …
D Fabbro, SW Cowan-Jacob, H Möbitz… - … inhibitors: methods and …, 2012 - Springer
Protein and lipid kinases fulfill essential roles in many signaling pathways that regulate normal cell functions. Deregulation of these kinase activities lead to a variety of pathologies …
N Seetharamu, PA Ott, AC Pavlick - The oncologist, 2010 - academic.oup.com
Abstract Learning Objectives After completing this course, the reader will be able to: Differentiate mucosal melanoma from cutaneous melanoma and describe its etiology …
Purpose: To determine the maximum tolerated dose, dose-limiting toxicity (DLT), and recommended phase II dose of dasatinib in metastatic solid tumors refractory to standard …
Y Xiong, M Taleb, K Misawa, Z Hou, S Banerjee… - Nature Cancer, 2023 - nature.com
The limited efficacy of chimeric antigen receptor (CAR) T cell therapy for solid tumors necessitates engineering strategies that promote functional persistence in an …
Tumor cells interact with the microenvironment that specifically supports and promotes tumor development. Key components in the tumor environment have been linked to various …
L Giorgioni, A Ambrosone, MF Cometa… - International Journal of …, 2024 - mdpi.com
Chimeric antigen receptor (CAR) T-cell therapy has achieved notable success in treating hematological cancers but faces significant challenges in solid-tumor treatment and overall …