Therapeutic strategies targeting respiratory recovery after spinal cord injury: from preclinical development to clinical translation

P Michel-Flutot, MA Lane, AC Lepore, S Vinit - Cells, 2023 - mdpi.com
High spinal cord injuries (SCIs) lead to permanent functional deficits, including respiratory
dysfunction. Patients living with such conditions often rely on ventilatory assistance to …

Enhancing neural activity to drive respiratory plasticity following cervical spinal cord injury

KM Hormigo, LV Zholudeva, VM Spruance… - Experimental …, 2017 - Elsevier
Cervical spinal cord injury (SCI) results in permanent life-altering sensorimotor deficits,
among which impaired breathing is one of the most devastating and life-threatening. While …

Diaphragm motor-evoked potential induced by cervical magnetic stimulation following cervical spinal cord contusion in the rat

KZ Lee, LM Liou, S Vinit - Journal of Neurotrauma, 2021 - liebertpub.com
Cervical spinal injury is typically associated with respiratory impairments due to damage to
bulbospinal respiratory pathways and phrenic motoneurons. Magnetic stimulation is a non …

Rostral-caudal effect of cervical magnetic stimulation on the diaphragm motor evoked potential after cervical spinal cord contusion in the rat

KZ Lee, LM Liou, S Vinit, MY Ren - Journal of Neurotrauma, 2022 - liebertpub.com
The present study was designed to investigate the rostral-caudal effect of spinal magnetic
stimulation on diaphragmatic motor-evoked potentials after cervical spinal cord injury. The …

Transneuronal tracing to map connectivity in injured and transplanted spinal networks

TA Fortino, ML Randelman, AA Hall, J Singh… - Experimental …, 2022 - Elsevier
It has become widely appreciated that the spinal cord has significant neuroplastic potential,
is not hard-wired, and that with traumatic injury and anatomical plasticity, the networks that …

Respiratory plasticity following spinal cord injury: perspectives from mouse to man

KC Locke, ML Randelman, DJ Hoh… - Neural regeneration …, 2022 - journals.lww.com
The study of respiratory plasticity in animal models spans decades. At the bench,
researchers use an array of techniques aimed at harnessing the power of plasticity within …

Volitional inspiration is mediated by two independent output channels in the primary motor cortex

LB Helou, RP Dum - Journal of Comparative Neurology, 2023 - Wiley Online Library
The diaphragm is a multifunctional muscle that mediates both autonomic and volitional
inspiration. It is critically involved in vocalization, postural stability, and expulsive core–trunk …

Supraspinal respiratory plasticity following acute cervical spinal cord injury

T Bezdudnaya, V Marchenko, LV Zholudeva… - Experimental …, 2017 - Elsevier
Impaired breathing is a devastating result of high cervical spinal cord injuries (SCI) due to
partial or full denervation of phrenic motoneurons, which innervate the diaphragm–a primary …

Position effect of trans-spinal magnetic stimulation on diaphragmatic motor evoked potential in healthy humans

MY Ren, LM Liou, S Vinit… - Journal of Applied …, 2022 - journals.physiology.org
The present study was designed to evaluate the rostrocaudal and lateral-midline effects of
trans-spinal magnetic stimulation on diaphragmatic motor evoked potential by utilizing a …

High frequency repetitive Transcranial Magnetic Stimulation promotes long lasting phrenic motoneuron excitability via GABAergic networks

P Michel-Flutot, LV Zholudeva, ML Randelman… - Respiratory physiology …, 2021 - Elsevier
Repetitive transcranial magnetic stimulation (rTMS) is a promising, innovative, and non-
invasive therapy used clinically. Efficacy of rTMS has been demonstrated to ameliorate …