Next-generation sequencing technology: current trends and advancements

H Satam, K Joshi, U Mangrolia, S Waghoo, G Zaidi… - Biology, 2023 - mdpi.com
Simple Summary Next-generation sequencing (NGS) is a powerful tool used in genomics
research. NGS can sequence millions of DNA fragments at once, providing detailed …

Third-generation sequencing in the clinical laboratory: exploring the advantages and challenges of nanopore sequencing

LM Petersen, IW Martin, WE Moschetti… - Journal of clinical …, 2019 - Am Soc Microbiol
Metagenomic sequencing for infectious disease diagnostics is an important tool that holds
promise for use in the clinical laboratory. Challenges for implementation so far include high …

Association between smoking history and tumor mutation burden in advanced non–small cell lung cancer

X Wang, B Ricciuti, T Nguyen, X Li, MS Rabin… - Cancer research, 2021 - AACR
Lung carcinogenesis is a complex and stepwise process involving accumulation of genetic
mutations in signaling and oncogenic pathways via interactions with environmental factors …

PARP inhibitors as a therapeutic agent for homologous recombination deficiency in breast cancers

MYT Keung, Y Wu, JV Vadgama - Journal of clinical medicine, 2019 - mdpi.com
Poly (ADP-ribose) polymerases (PARPs) play an important role in various cellular
processes, such as replication, recombination, chromatin remodeling, and DNA repair …

Applications and biocompatibility of mesoporous silica nanocarriers in the field of medicine

C Zhang, H Xie, Z Zhang, B Wen, H Cao… - Frontiers in …, 2022 - frontiersin.org
Mesoporous silica nanocarrier (MSN) preparations have a wide range of medical
applications. Studying the biocompatibility of MSN is an important part of clinical …

Enhanced immune response outperform aggressive cancer biology and is associated with better survival in triple-negative breast cancer

M Oshi, A Patel, R Wu, L Le, Y Tokumaru… - NPJ Breast …, 2022 - nature.com
Although the value of tumor-infiltrating lymphocytes is well known, the clinical relevance of
an increased immune response, specifically in breast cancer, has not been investigated …

Proportion of unresectable pancreatic cancer specimens obtained by endoscopic ultrasound-guided tissue acquisition meeting the OncoGuide™ NCC Oncopanel …

Y Hisada, S Hijioka, G Ikeda, K Maehara… - Journal of …, 2022 - Springer
Background There are limited studies on the results of comprehensive genomic profiling
testing for pancreatic cancer tissue specimens by endoscopic ultrasound-guided tissue …

A custom DNA-based NGS panel for the molecular characterization of patients with diffuse gliomas: diagnostic and therapeutic applications

E Tirrò, M Massimino, G Broggi, C Romano… - Frontiers in …, 2022 - frontiersin.org
The management of patients with Central Nervous System (CNS) malignancies relies on the
appropriate classification of these tumors. Recently, the World Health Organization (WHO) …

Circulating exosome cargoes contain functionally diverse cancer biomarkers: from biogenesis and function to purification and potential translational utility

MI Mitchell, J Ma, CL Carter, O Loudig - Cancers, 2022 - mdpi.com
Simple Summary The indolent nature of some cancers makes early detection challenging,
as such significant effort is placed on identifying circulating cancer biomarkers using …

[HTML][HTML] KRAS mutations testing in non-small cell lung cancer: The role of Liquid biopsy in the basal setting

M Nacchio, R Sgariglia, V Gristina… - Journal of thoracic …, 2020 - ncbi.nlm.nih.gov
In advanced stage non-small cell lung cancer (NSCLC) patients, Kirsten Rat Sarcoma Viral
Oncogene Homolog (KRAS) testing may soon acquire a predictive significance to select …