Our ability to design completely de novo proteins is improving rapidly. This is true of all three
main approaches to de novo protein design, which we define as: minimal, rational and …

Motivation Coiled coils are widespread protein domains involved in diverse processes
ranging from providing structural rigidity to the transduction of conformational changes. They …

The molecular architecture and assembly mechanism of intermediate filaments have been
enigmatic for decades. Among those, lamin filaments are of particular interest due to their …