In many cases, the mechanical properties of a tumor are different from those of the host
tissue. Mechanical cues regulate cancer development by affecting both tumor cells and their …

Processes that are important in cancer progression, such as sustained cell growth, invasion
to other organs, and resistance to cell death inducers, have a clear overlap with pathways …

The past two decades have seen the identification of important roles for calcium signalling in
many of the hallmarks of cancer. One of the cancer types that has been a particular focus of …

Substrate stiffness (or rigidity) of the extracellular matrix has important functions in numerous
pathophysiological processes including fibrosis. Emerging data support a role for both a …

In healthy connective tissues, mechanosensors trigger the generation of Ca2+ signals,
which enable cells to maintain the structure of the fibrillar collagen matrix through …

Cellular processes are initiated and regulated by different stimuli, including mechanical
forces. Cell membrane mechanosensors represent the first step towards the conversion of …

Store-operated calcium entry (SOCE) is the predominant calcium entry mechanism in most
cancer cells. SOCE is mediated by the endoplasmic reticulum calcium sensor STIMs (STIM1 …

MicroRNAs (miRNAs) have a critical role in tumorigenesis and metastasis, which are major
obstacles of cancer therapy. However, the role of miRNAs in colorectal cancer (CRC) …

Transient receptor potential (TRP) channels are polymodal channels capable of sensing
environmental stimuli, which are widely expressed on the plasma membrane of cells and …

Breast cancer is the most common type of cancer in women. It is a heterogeneous disease
that ranges from the less undifferentiated luminal A to the more aggressive basal or triple …