I. Introduction II. 9S Receptors A. Estrogen receptors (ERs) B. Progesterone receptors (PRs)
C. Androgen receptors (ARs) D. Glucocorticoid receptors (GRs) E. Mineralocorticoid …

The glucocorticoid receptor (GR) belongs to the superfamily of steroid receptors and is an
important regulator of physiological and metabolic processes. In its inactive state, GR is …

We investigated the effects of mild oxidation on protein kinase C (PKC) using the
xanthine/xanthine oxidase system of generating superoxide. Exposure of various PKC …

The 90-kDa heat shock protein (hsp90) is a well conserved, abundant cytosolic protein
believed to be a “chaperone” of most steroid receptors. We have recently demonstrated that …

In this work, we used two approaches to localize the 90-kDa heat shock protein (hsp90)-
binding site within the hormone-binding domain of the glucocorticoid receptor. In the first …

We have carried out experiments to determine the role of the cysteines in the hormone-
binding domain (HBD) of the human estrogen receptor (ER) in receptor function. In each …

A series of chiral analogues of bicalutamide bearing electrophilic groups (isothiocyanate, N-
chloroacetyl, and N-bromoacetyl) on aromatic ring B of the parent molecule were …

Treatment of the transformed glucocorticoid receptor with hydrogen peroxide promotes the
formation of disulfide bonds and inhibits the ability of the receptor to bind to DNA …

Publisher Summary The amino acids that determine the steroid-binding sites of steroid
receptors are located in the COOH-terminal in a region referred to as the “horome-binding …

Catalase, an antioxidant enzyme responsible for degradation of hydrogen peroxide, is
protective in many diseases. The amino-acid homocysteine has been suggested to be a pro …