Background Azapirones are a group of drugs that work at the 5‐HT1A receptor and are used
to treat patients suffering from generalized anxiety disorder (GAD). However, several studies …

In recent years generalised anxiety disorder (GAD) has become a much better defined
disorder, with specific criteria distinguishing it from the other anxiety disorders; however, it …

Serotonergic dysfunction has been implicated in the aetiology of several psychiatric
conditions, including depressive and anxiety disorders. Much of the evidence for the role of …

Objective To investigate the bioavailability of rivastigmine, an approved therapy for patients
with mild to moderate dementia of the Alzheimer's type, at the highest approved single dose …

In clinical trials of dopamine-blocking antipsychotics, significant adverse events may occur in
healthy volunteers at dose levels that are well tolerated by schizophrenic patients. Because …

OBJECTIVE: To compare the relative efficacy and safety of lesopitron 40–80 mg/d versus
lorazepam 2–4 mg/d and placebo in a subgroup of patients with anxiety history taken from a …

Objective: This inpatient, randomised, three-way crossover study evaluated the steady-state
pharmacokinetics and tolerability of generic clozapine (Creighton) versus Clozaril®(Novartis …

Stimulation of 5-HT1A receptors appears to be the most plausible basis for the anxiolytic
effects of buspirone and has been hypothesized to explain effects of SSRIs in depression …

Antecedentes Las azapironas son un grupo de fármacos que actúan en el receptor 5-HT1A
y se usan para tratar a los pacientes que padecen trastornos de ansiedad generalizada …

The revolution in neurological therapeutics means that an increasing number of neurologists
will have the opportunity to participate in a drug development process that is long and …