How synthetic biology can help bioremediation

EL Rylott, NC Bruce - Current Opinion in Chemical Biology, 2020 - Elsevier
Abstract The World Health Organization reported that “an estimated 12.6 million people died
as a result of living or working in an unhealthy environment in 2012, nearly 1 in 4 of total …

[HTML][HTML] Genome engineering on size reduction and complexity simplification: A review

XR Chen, YZ Cui, BZ Li, YJ Yuan - Journal of Advanced Research, 2024 - Elsevier
Background Genome simplification is an important topic in the field of life sciences that has
attracted attention from its conception to the present day. It can help uncover the essential …

The synthetic biology open language (SBOL) version 3: simplified data exchange for bioengineering

JA McLaughlin, J Beal, G Mısırlı, R Grünberg… - … in Bioengineering and …, 2020 - frontiersin.org
The Synthetic Biology Open Language (SBOL) is a community-developed data standard that
allows knowledge about biological designs to be captured using a machine-tractable …

Integration of yeast episomal/integrative plasmid causes genotypic and phenotypic diversity and improved sesquiterpene production in metabolically engineered …

B Peng, SJ Weintraub, Z Lu, S Evans… - ACS Synthetic …, 2023 - ACS Publications
The variability in phenotypic outcomes among biological replicates in engineered microbial
factories presents a captivating mystery. Establishing the association between phenotypic …

Fast and efficient template-mediated synthesis of genetic variants

L Liu, Y Huang, HH Wang - Nature Methods, 2023 - nature.com
Efficient methods for the generation of specific mutations enable the study of functional
variations in natural populations and lead to advances in genetic engineering applications …

Quantification of synthetic errors during chemical synthesis of DNA and its suppression by non-canonical nucleosides

Y Masaki, Y Onishi, K Seio - Scientific Reports, 2022 - nature.com
Substitutions, insertions, and deletions derived from synthetic oligonucleotides are the
hurdles for the synthesis of long DNA such as genomes. We quantified these synthetic errors …

Current state and future directions of genetics and genomics of endophytic fungi for bioprospecting efforts

R Sagita, WJ Quax, K Haslinger - Frontiers in Bioengineering and …, 2021 - frontiersin.org
The bioprospecting of secondary metabolites from endophytic fungi received great attention
in the 1990s and 2000s, when the controversy around taxol production from Taxus spp …

Computer-aided whole-cell design: taking a holistic approach by integrating synthetic with systems biology

L Marucci, M Barberis, J Karr, O Ray… - … in Bioengineering and …, 2020 - frontiersin.org
Computer-aided design (CAD) for synthetic biology promises to accelerate the rational and
robust engineering of biological systems. It requires both detailed and quantitative …

Seeding the idea of encapsulating a representative synthetic metagenome in a single yeast cell

I Belda, TC Williams, M de Celis, IT Paulsen… - Nature …, 2021 - nature.com
Synthetic metagenomics could potentially unravel the complexities of microbial ecosystems
by revealing the simplicity of microbial communities captured in a single cell …

Engineered yeast genomes accurately assembled from pure and mixed samples

JH Collins, KW Keating, TR Jones, S Balaji… - Nature …, 2021 - nature.com
Yeast whole genome sequencing (WGS) lacks end-to-end workflows that identify genetic
engineering. Here we present Prymetime, a tool that assembles yeast plasmids and …