Aldehyde dehydrogenases engage in many cellular functions, however their dysfunction
resulting in accumulation of their substrates can be cytotoxic. ALDHs are responsible for the …

Most cancers contain a small sub-population of cells that are endowed with self-renewal,
multipotency, and a unique potential for tumor initiation. These properties are considered …

Members of the aldehyde dehydrogenase gene (ALDH) superfamily play an important role
in the enzymic detoxification of endogenous and exogenous aldehydes and in the formation …

Gene duplications are believed to facilitate evolutionary innovation. However, the
mechanisms shaping the fate of duplicated genes remain heavily debated because the …

Elevated aldehyde dehydrogenase (ALDH) activity correlates with poor outcome for many
solid tumors as ALDHs may regulate cell proliferation and chemoresistance of cancer stem …

Background The characterization of protein binding sites is a major challenge in
computational biology. Proteins interact with a wide variety of molecules and understanding …

The study of the evolutionary origin of vertebrates has been linked to the study of genome
duplications since Susumo Ohno suggested that the successful diversification of vertebrate …

Glioblastoma multiforme (GBM) is the deadliest form of brain tumor. It is known for its ability
to escape the therapeutic options available to date thanks to the presence of a subset of …

The aldehyde dehydrogenase family 1 member A3 (ALDH1A3) catalyzes the oxidation of
retinal to the pleiotropic factor retinoic acid using NAD+. The level of ALDHs enzymatic …

Head and neck squamous cell carcinomas (HNSCCs) arise in the mucosal linings of the
upper aerodigestive tract and are heterogeneous in nature. Risk factors for HNSCCs are …