A fundamental goal in cancer research is to understand the mechanisms of cell transformation. This is key to developing more efficient cancer detection methods and …
Despite decades of laboratory, epidemiological and clinical research, breast cancer incidence continues to rise. Breast cancer remains the leading cancer-related cause of …
The etiopathogenesis of endometriosis is a multifactorial process resulting in a heterogeneous disease. Considering that endometriosis etiology and pathogenesis are still …
PG Pilié, C Tang, GB Mills, TA Yap - Nature reviews Clinical oncology, 2019 - nature.com
Genomic instability is a key hallmark of cancer that arises owing to defects in the DNA damage response (DDR) and/or increased replication stress. These alterations promote the …
RL Coleman, AM Oza, D Lorusso, C Aghajanian… - The Lancet, 2017 - thelancet.com
Background Rucaparib, a poly (ADP-ribose) polymerase inhibitor, has anticancer activity in recurrent ovarian carcinoma harbouring a BRCA mutation or high percentage of genome …
GM Findlay, RM Daza, B Martin, MD Zhang, AP Leith… - Nature, 2018 - nature.com
Variants of uncertain significance fundamentally limit the clinical utility of genetic information. The challenge they pose is epitomized by BRCA1, a tumour suppressor gene in which …
In vertebrate cells, the DNA damage response is controlled by three related kinases: ATM, ATR, and DNA-PK. It has been 20 years since the cloning of ATR, the last of the three to be …
PARP inhibitors (PARPi), a cancer therapy targeting poly (ADP-ribose) polymerase, are the first clinically approved drugs designed to exploit synthetic lethality, a genetic concept …
Mutations in BRCA1 and BRCA2 predispose individuals to certain cancers,–, and disease- specific screening and preventative strategies have reduced cancer mortality in affected …